| Gene Symbol | SESN3 |
| Full Name | Sestrin 3 |
| Aliases | SESN3PROTEIN |
| Chromosome | 11q21<br> |
| Function | SESN3 shares functional similarities with other sestrins (SESN1 and SESN2): |
| Primary Expression | various tissues: - Brain: cortex, hippocampus, cerebellum - Liver, kidney, muscle - Inducible b |
| Subcellular Localization | ** Cytoplasm, Nucleus<br> |
| Molecular Weight | 49 kDa |
| Pathways | signaling: - AMPK senses cellular energy status, mTOR, AMPK, AMPK signaling |
| UniProt ID | Q9Y5P4 |
| NCBI Gene ID | 286826 |
| Ensembl ID | ENSG00000148231 |
| GeneCards | SESN3 |
| Human Protein Atlas | SESN3 |
| N-terminal domain | Binds to GATOR2 complex for mTORC1 inhibition |
| Associated Diseases | Alzheimer's Disease, Parkinson's Disease, Metabolic Disease |
| KG Connections | 13 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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