gene

DNAJB12

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DNAJB12: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

6Connections

0Hypotheses

0Analyses

6Outgoing

0Incoming

0Experiments

0Debates

Summary

Comprehensive coverage of DNAJB12 in protein quality control, ER stress response, and neurodegenerative diseases including ALS, Parkinson's, and Huntington's disease

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	DNAJB12
Full Name	DnaJ Heat Shock Protein Family (Hsp40) Member B12
Chromosome	10q24.3
Protein Type	Chaperone
Function	is a crucial co-chaperone protein that plays essential roles in protein quality control, ER-associated degradation (ERAD), and cellular proteostasis.
Subcellular Localization	DNAJB12 exhibits dual localization:
Molecular Weight	36 kDa
Amino Acids	324 aa
UniProt ID	Q9Y5W2
Ensembl ID	ENSG00000135924
GeneCards	DNAJB12
Human Protein Atlas	DNAJB12
Cytosolic form	Functions in cytosolic protein quality control, interacting with Hsc70/Hsp70-1A
ER-localized form	Partners with BiP (GRP78) in the ER for ERAD pathway function
J-domain-mediated activation	The J-domain stimulates ATP hydrolysis by Hsp70 partners, converting them to their high-affinity substrate-bound state
Associated Diseases	Amyotrophic Lateral Sclerosis, Parkinson's Disease, Huntington's Disease
KG Connections	6 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: DNAJB12 — AlphaFold Q9Y5W2 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

DNAJB12 — DnaJ Heat Shock Protein Family (Hsp40) Member B12

gene · 1660 words

→

Pathway Diagram

graph TD
    DNAJB12["DNAJB12"]
    Anxiety{"Anxiety"}
    DNAJB12 -->|"activates"| Anxiety
    Ms{"Ms"}
    DNAJB12 -->|"regulates"| Ms
    Depression{"Depression"}
    DNAJB12 -->|"activates"| Depression
    RB1CC1["RB1CC1"]
    DNAJB12 -->|"regulates"| RB1CC1
    SCN4B["SCN4B"]
    DNAJB12 -->|"regulates"| SCN4B
    STK4["STK4"]
    DNAJB12 -->|"regulates"| STK4
    neurodegeneration["neurodegeneration"]
    DNAJB12 -->|"implicated in"| neurodegeneration
    style DNAJB12 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (6)

Target	Relation	Type	Str
Anxiety	activates	disease	0.65
Ms	regulates	disease	0.65
Depression	activates	disease	0.65
RB1CC1	regulates	gene	0.60
SCN4B	regulates	gene	0.60
STK4	regulates	gene	0.60

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DNAJB12 in their description or question text

No additional research found