gene

RTN4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RTN4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

14Connections

0Hypotheses

0Analyses

10Outgoing

4Incoming

0Experiments

0Debates

Summary

RTN4 (Reticulon 4, Nogo) encodes reticulon proteins regulating ER morphology, neurite outgrowth inhibition, and oligodendrocyte biology. Key roles in neurodegeneration through its Nogo-A isoform.

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🧬 Gene Info

Gene Symbol	RTN4
Full Name	Reticulon 4
Aliases	Reticulon 4, Nogo
Chromosome	22q11.21
Function	encodes a family of reticulon proteins with three major isoforms: Nogo-A, Nogo-B, and Nogo-C[@schwab2010].
Primary Expression	neurons and oligodendrocytes, where it acts through the Nogo-66 receptor (NgR) and its coreceptor
Molecular Weight	200 kDa
Amino Acids	66 aa
Pathways	Autophagy
UniProt ID	Q9NPD4
NCBI Gene ID	57142
Ensembl ID	ENSG00000145113
OMIM	604569
GeneCards	RTN4
Human Protein Atlas	RTN4
Associated Diseases	Alzheimer's disease, Parkinson's disease, ALS
Interactions	BAI1, BECN1, MAP1LC3B
KG Connections	14 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: RTN4 — AlphaFold Q9NPD4 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

RTN4 Gene

gene · 1458 words

→

RTN4 Protein (Nogo)

protein · 996 words

→

Pathway Diagram

graph TD
    RTN4["RTN4"]
    Ms{"Ms"}
    RTN4 -->|"interacts with"| Ms
    neurodegeneration["neurodegeneration"]
    RTN4 -->|"implicated in"| neurodegeneration
    BAI1["BAI1"]
    BAI1 -->|"interacts with"| RTN4
    BECN1["BECN1"]
    BECN1 -->|"activates"| RTN4
    MAP1LC3B["MAP1LC3B"]
    MAP1LC3B -->|"activates"| RTN4
    style RTN4 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (10)

Target	Relation	Type	Str
Ms	interacts_with	disease	0.65
Autophagy	regulates	pathway	0.60
Angiogenesis	activates	pathway	0.60
NOGO	regulates	gene	0.60
BAI1	interacts_with	gene	0.60
SYNAPSE	regulates	gene	0.60
autophagy pathway	participates_in	pathway	0.60
neurons	expressed_in	cell_type	0.60
Thalamus	expressed_in	brain_region	0.55
Neuron	expressed_in	cell_type	0.55

Incoming (4)

Source	Relation	Type	Str
BAI1	interacts_with	gene	0.60
AUTOPHAGY	regulates	gene	0.60
BECN1	activates	gene	0.50
MAP1LC3B	activates	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning RTN4 in their description or question text

No additional research found