gene

PPT1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PPT1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

21Connections

0Hypotheses

0Analyses

9Outgoing

12Incoming

0Experiments

0Debates

Summary

Page for PPT1 Gene - Palmitoyl-Protein Thioesterase 1

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🧬 Gene Info

Gene Symbol	PPT1
Aliases	Page for PPT1 Gene, Palmitoyl-Protein Thioesterase 1
Chromosome	1p34.2
Protein Family	Palmitoyl-protein thioesterase family
Protein Type	Enzyme
Function	### Enzymatic Activity
Primary Expression	neurons and glia - Cellular Localization: Lysosomal lumen - Developmental Expression: High during fetal development and e
Molecular Weight	34 kDa
Amino Acids	306 aa
Exons	9
UniProt ID	P60617
NCBI Gene ID	5538
Ensembl ID	ENSG00000131238
OMIM	256730
GeneCards	PPT1
Human Protein Atlas	PPT1
Associated Diseases	neurodegeneration
Interactions	AUTOPHAGY, ENDOSOMES, FERROPTOSIS, IFN, SELF-DNA, TNF
KG Connections	21 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: PPT1 — AlphaFold P60617 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    PPT1["PPT1"]
    PPT1 -->|"inhibits"| Als["Als"]
    PPT1 -->|"activates"| Ferroptosis["Ferroptosis"]
    PPT1 -->|"inhibits"| Cancer["Cancer"]
    PPT1 -->|"activates"| Macrophage["Macrophage"]
    PPT1 -->|"activates"| Dendritic_Cell["Dendritic Cell"]
    PPT1 -->|"inhibits"| Autophagy["Autophagy"]
    PPT1 -->|"target for"| Ras["Ras"]
    PPT1 -->|"implicated in"| neurodegeneration["neurodegeneration"]
    SELF_DNA["SELF-DNA"] -->|"inhibits"| PPT1
    ENDOSOMES["ENDOSOMES"] -->|"inhibits"| PPT1
    TLR9["TLR9"] -->|"regulates"| PPT1
    IFN["IFN"] -->|"inhibits"| PPT1
    TNF["TNF"] -->|"activates"| PPT1
    FERROPTOSIS["FERROPTOSIS"] -->|"activates"| PPT1
    AUTOPHAGY["AUTOPHAGY"] -->|"inhibits"| PPT1

Outgoing (9)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:PPT1	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
Ferroptosis	activates	disease	0.65
Als	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Macrophage	activates	cell_type	0.60
Ras	therapeutic_target	protein	0.60
Dendritic Cell	activates	cell_type	0.60
Autophagy	inhibits	pathway	0.60

Incoming (12)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:PPT1	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
STING	regulates	gene	0.65
TMEM106B	exacerbates	gene	0.65
CLN1	causes	gene	0.60
FERROPTOSIS	activates	gene	0.60
AUTOPHAGY	inhibits	gene	0.60
SELF-DNA	inhibits	gene	0.60
ENDOSOMES	inhibits	gene	0.60
IFN	inhibits	gene	0.60
TLR9	regulates	gene	0.60
TNF	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PPT1 in their description or question text

No additional research found