| Gene Symbol | PP2B |
| Aliases | Calcineurin |
| Function | Calcineurin exists as a heterodimer composed of a catalytic A subunit (approximately 59-64 kDa) and a calcium-binding regulatory B subunit (approximately 19 kDa). |
| Subcellular Localization | </strong></td><td>Cytoplasm, Nucleus, Synaptic vesicles</td></tr> |
| Molecular Weight | 59 kDa |
| Amino Acids | 521 aa |
| Pathways | calcium signaling |
| GeneCards | PP2B |
| Human Protein Atlas | PP2B |
| N-terminal domain | Variable region involved in targeting and regulatory interactions |
| Catalytic domain | The conserved phosphatase domain (residues ~100-340) containing the metal-dependent active site |
| Calmodulin-binding domain | Auto-inhibitory region that blocks the active site in the absence of calcium-calmodulin |
| Tail region | C-terminal regulatory sequences |
| Four EF-hand motifs | Two functional calcium-binding sites and two degenerate "pseudo" sites |
| N-terminal myristylation site | Promotes membrane association |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Interactions | NFAT1, NFAT2 |
| KG Connections | 9 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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