Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NFAT2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Nuclear Factor of Activated T-Cells 2 - calcium-dependent transcription factor in neuroinflammation and neurodegenerative disease
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| Gene Symbol | NFAT2 |
| Full Name | Nuclear Factor of Activated T Cells 2 |
| Aliases | Nuclear Factor of Activated T-Cells 2 |
| Chromosome | 18q23 |
| Protein Type | Transcription Factor |
| Function | NFAT2 functions as a calcium-dependent transcription factor with diverse roles across multiple organ systems. |
| Primary Expression | neurons, astrocytes, and microglia, where it transduces calcium signals into gene expression changes that influence neurodegenerative processes |
| Molecular Weight | 99 kDa |
| Pathways | calcium signaling |
| Ensembl ID | ENSG00000106436 |
| GeneCards | NFAT2 |
| Human Protein Atlas | NFAT2 |
| DNA Binding | NFAT2 binds to NFAT response elements (TGTTTCCA motifs) in the promoters and enhancers of target genes. |
| Co-factor Interactions | NFAT2 interacts with various co-activators and co-repressors to modulate transcription. |
| Alternative Splicing | Multiple NFAT2 isoforms with distinct transcriptional properties are generated through alternative splicing. |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Interactions | NFAT1, PP2B |
| KG Connections | 4 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
NFAT2(["NFAT2"])
style NFAT2 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff
PP2B(["PP2B"])
calcium_signaling(["calcium signaling"])
T_cells(["T cells"])
NFAT1(["NFAT1"])
neurodegeneration["neurodegeneration"]
NFAT2 -->|"activates"| PP2B
NFAT2 -->|"participates_in"| calcium_signaling
NFAT2 -->|"expressed_in"| T_cells
NFAT1 -->|"activates"| NFAT2
NFAT2 -->|"implicated_in"| neurodegeneration
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
classDef drug fill:#1a2a2a,stroke:#80cbc4,color:#e0e0e0
class PP2B protein
class calcium_signaling protein
class T_cells protein
class NFAT1 protein
class neurodegeneration disease| Target | Relation | Type | Str |
|---|---|---|---|
| calcium signaling | participates_in | pathway | 0.55 |
| PP2B | activates | gene | 0.55 |
| T cells | expressed_in | cell_type | 0.55 |
| Source | Relation | Type | Str |
|---|---|---|---|
| NFAT1 | activates | gene | 0.55 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning NFAT2 in their description or question text
No additional research found