gene

PHOX2B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PHOX2B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

21Connections

0Hypotheses

0Analyses

18Outgoing

3Incoming

0Experiments

0Debates

Summary

PHOX2B (Paired Homeobox 2B) - transcription factor master regulator of autonomic nervous system development, dopaminergic neuron specification, and neurodegenerative disease pathogenesis including Alzheimer's and Parkinson's disease

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🧬 Gene Info

Gene Symbol	PHOX2B
Full Name	Paired Homeobox 2B
Chromosome	4p13
Protein Family	Paired homeobox transcription factors
Protein Type	Transcription Factor
Function	encodes a critical transcription factor that serves as a master regulator of autonomic nervous system (ANS) development.
Primary Expression	dopaminergic neurons of the substantia nigra pars compacta, a region critically affected in [Parkinson's disease](/
Amino Acids	314 aa
UniProt ID	Q75WG7
NCBI Gene ID	9088
Ensembl ID	ENSG00000178363
OMIM	603851
GeneCards	PHOX2B
Human Protein Atlas	PHOX2B
Associated Diseases	Parkinson's disease, Alzheimer's disease
KG Connections	21 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: PHOX2B — AlphaFold Q75WG7 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

PHOX2B Gene

gene · 2326 words

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PHOX2B Neurons

cell · 727 words

→

Pathway Diagram

graph TD
    PHOX2B["PHOX2B"]
    Als{"Als"}
    PHOX2B -->|"therapeutic target"| Als
    Cancer{"Cancer"}
    PHOX2B -->|"therapeutic target"| Cancer
    Tumor{"Tumor"}
    PHOX2B -->|"therapeutic target"| Tumor
    PI3K["PI3K"]
    PHOX2B -->|"therapeutic target"| PI3K
    AKT["AKT"]
    PHOX2B -->|"therapeutic target"| AKT
    BIRC5["BIRC5"]
    PHOX2B -->|"therapeutic target"| BIRC5
    CANCER["CANCER"]
    PHOX2B -->|"therapeutic target"| CANCER
    MDM2["MDM2"]
    PHOX2B -->|"therapeutic target"| MDM2
    Akt(["Akt"])
    PHOX2B -->|"therapeutic target"| Akt
    Mtor(["Mtor"])
    PHOX2B -->|"therapeutic target"| Mtor
    Epigenetic(["Epigenetic"])
    PHOX2B -->|"therapeutic target"| Epigenetic
    Mapk(["Mapk"])
    PHOX2B -->|"therapeutic target"| Mapk
    MTOR["MTOR"]
    MTOR -->|"therapeutic target"| PHOX2B
    style PHOX2B fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (18)

Target	Relation	Type	Str
Tumor	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Neuroblastoma	therapeutic_target	disease	0.65
RAS	therapeutic_target	gene	0.60
Pi3K/Akt	therapeutic_target	pathway	0.60
OVERVIEW	therapeutic_target	gene	0.60
MTOR	therapeutic_target	gene	0.60
PI3K	therapeutic_target	gene	0.60
AKT	therapeutic_target	gene	0.60
BIRC5	therapeutic_target	gene	0.60
MDM2	therapeutic_target	gene	0.60
Epigenetic	therapeutic_target	pathway	0.60
Mapk	therapeutic_target	pathway	0.60
CANCER	therapeutic_target	gene	0.60
Pi3K	therapeutic_target	pathway	0.60
Akt	therapeutic_target	pathway	0.60
Mtor	therapeutic_target	pathway	0.60

Incoming (3)

Source	Relation	Type	Str
BIRC5	therapeutic_target	gene	0.60
PI3K	therapeutic_target	gene	0.60
MTOR	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PHOX2B in their description or question text

No additional research found