protein

P53PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about P53PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Tumor Protein P53 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

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🔬 Protein Info

Gene Symbol	P53PROTEIN
Protein Type	Transcription Factor
Function	is an important component in the neurobiology of neurodegenerative diseases.
Subcellular Localization	signals The protein functions as a homotetramer, with each monomer containing 3
Amino Acids	4477 aa
GeneCards	P53PROTEIN
Human Protein Atlas	P53PROTEIN
N-terminal Transactivation Domain (TAD)	Contains two subdomains (TAD1, TAD2) for transcriptional activation
Proline-Rich Domain (PRD)	Mediates protein-protein interactions
Central DNA-Binding Domain (DBD)	Binds to p53 response elements (p53 RE) as a tetramer
Oligomerization Domain (OD)	Forms tetramers essential for DNA binding
C-terminal Regulatory Domain (CTD)	Modulates DNA binding and contains nuclear localization signals
Cell Cycle Arrest	Activates p21 to halt cell cycle progression
[Apoptosis](/entities/apoptosis)	Induces pro-apoptotic genes (BAX, PUMA, NOXA)
DNA Repair	Upregulates DNA repair proteins
Associated Diseases	aging, Als, Alzheimer, Alzheimer's disease
Known Drugs/Compounds	APR-246, chemotherapy, Emodin, MDM2 antagonist Nutlin-3, rapamycin, RAPAMYCIN
Interactions	ACAT1, ACETYL-COA, ACOX1, ACSL4, Actin, ACVR2A
KG Connections	2555 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Tumor Protein P53

protein · 599 words

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Pathway Diagram

graph TD
    P53PROTEIN["P53PROTEIN"]
    neurodegeneration["neurodegeneration"]
    P53PROTEIN -->|"implicated_in"| neurodegeneration
    style P53PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning P53PROTEIN in their description or question text

No additional research found