protein

NEUROFILAMENT LIGHT CHAIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NEUROFILAMENT LIGHT CHAIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

22Connections

1Hypotheses

0Analyses

15Outgoing

7Incoming

0Experiments

0Debates

Summary

Page for Neurofilament Light Chain Protein

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🔬 Protein Info

Gene Symbol	NEUROFILAMENT LIGHT CHAIN
Molecular Weight	61.5 kDa
Amino Acids	543 aa
NfL (Light chain, 61 kDa)	The smallest subunit, essential for filament assembly
NfM (Medium chain, 95 kDa)	Phosphorylated on serine residues in the tail domain
NfH (Heavy chain, 200 kDa)	Heavily phosphorylated, regulates axonal caliber
Associated Diseases	Amyotrophic Lateral Sclerosis, Multiple Sclerosis
Interactions	AMYLOID, IL10, IL18, PHOSPHORYLATED TAU
KG Connections	16 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

neurofilament-light-chain

biomarker · 1290 words

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Pathway Diagram

graph TD
    NEUROFILAMENT_LIGHT_CHAIN["NEUROFILAMENT LIGHT CHAIN"]
    NEUROFILAMENT_LIGHT_CHAIN -.biomarker for.-> Neuro_Axonal_Injury["Neuro-Axonal Injury"]
    NEUROFILAMENT_LIGHT_CHAIN -.biomarker for.-> Neurodegeneration["Neurodegeneration"]
    NEUROFILAMENT_LIGHT_CHAIN -->|"involved_in"| Neurological_Disease_Managemen["Neurological Disease Management"]
    NEUROFILAMENT_LIGHT_CHAIN -->|"activates"| PHOSPHORYLATED_TAU["PHOSPHORYLATED TAU"]
    NEUROFILAMENT_LIGHT_CHAIN -->|"activates"| AMYLOID["AMYLOID"]
    NEUROFILAMENT_LIGHT_CHAIN -->|"activates"| CYTOKINES["CYTOKINES"]
    NEUROFILAMENT_LIGHT_CHAIN -->|"activates"| TAU_PATHOLOGY["TAU PATHOLOGY"]
    NEUROFILAMENT_LIGHT_CHAIN -->|"activates"| ENDOTHELIAL["ENDOTHELIAL"]
    Neurodegeneration -->|"activates"| NEUROFILAMENT_LIGHT_CHAIN
    IL10["IL10"] -->|"activates"| NEUROFILAMENT_LIGHT_CHAIN
    IL18["IL18"] -->|"activates"| NEUROFILAMENT_LIGHT_CHAIN

Outgoing (15)

Target	Relation	Type	Str
Neuro-Axonal Injury	biomarker_for	process	0.95
Neurodegeneration	biomarker_for	process	0.95
Amyotrophic Lateral Sclerosis	associated_with	disease	0.90
Multiple Sclerosis	associated_with	disease	0.90
Amyotrophic Lateral Sclerosis	biomarker_for	disease	0.85
Neurological Disease Management	involved_in	process	0.85
NEUROGRANIN	associated_with	protein	0.50
PHOSPHORYLATED TAU	activates	protein	0.50
α-SYNUCLEIN	associated_with	concept	0.50
SYNUCLEIN	associated_with	concept	0.50
AMYLOID	activates	gene	0.50
CYTOKINES	activates	concept	0.50
TAU PATHOLOGY	activates	concept	0.50
ENDOTHELIAL	activates	concept	0.50
SNAP-25	associated_with	protein	0.50

Incoming (7)

Source	Relation	Type	Str
Neurodegeneration	associated_with	disease	0.50
Neurodegeneration	activates	disease	0.50
IL10	activates	gene	0.50
IL18	activates	gene	0.50
TREM2	associated_with	gene	0.50
Neuroinflammation	associated_with	process	0.50
YKL-40	associated_with	protein	0.50

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
CSF Neurofilament Light Chain-Guided Astrocyte-Derived Extra	0.461	molecular neurobiology	View

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NEUROFILAMENT LIGHT CHAIN in their description or question text

No additional research found