| Gene Symbol | NFAT2 |
| Full Name | Nuclear Factor of Activated T Cells 2 |
| Aliases | Nuclear Factor of Activated T-Cells 2 |
| Chromosome | 18q23 |
| Protein Type | Transcription Factor |
| Function | NFAT2 functions as a calcium-dependent transcription factor with diverse roles across multiple organ systems. |
| Primary Expression | neurons, astrocytes, and microglia, where it transduces calcium signals into gene expression changes that influence neurodegenerative processes |
| Molecular Weight | 99 kDa |
| Pathways | calcium signaling |
| Ensembl ID | ENSG00000106436 |
| GeneCards | NFAT2 |
| Human Protein Atlas | NFAT2 |
| NFAT Response Element (NFAT-RE) | DNA sequence 5'-GGGAA(A/T)-3' bound by NFAT proteins |
| Calcineurin-Binding Site | Highly conserved motif in the regulatory domain |
| Multiple Phosphorylation Sites | Ser/Thr residues for kinase and phosphatase regulation |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Interactions | NFAT1, PP2B |
| KG Connections | 4 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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