gene

ANO6

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ANO6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1Connections

0Hypotheses

1Analyses

0Outgoing

1Incoming

0Experiments

1Debates

Summary

ano6

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🧬 Gene Info

Gene Symbol	ANO6
Full Name	Anoctamin 6
Chromosome	12q24.11
Protein Family	Anoctamin/TMEM16
Function	ANO6 has distinctive dual functions
Primary Expression	immune cells, platelets, and various tissues including the brain
GeneCards	ANO6
Human Protein Atlas	ANO6
Calcium-activated chloride channel	Mediates chloride flux in response to intracellular calcium [@yang2008]
Phospholipid scramblase	Facilitates bidirectional transbilayer movement of plasma membrane phospholipids [@suzuki2010]
Cellular roles	Essential for platelet procoagulant activity, cell fusion, and apoptosis [@segawa2014]
Tissue distribution	Broad expression including brain, immune cells, endothelial cells [@framework]
Associated Diseases	neurodegeneration
KG Connections	1 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

ano6

gene · 932 words

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Pathway Diagram

graph TD
    ANO6["ANO6 (TMEM16F)
Phospholipid Scramblase"]
    PS_exposure["Phosphatidylserine
Externalization"]
    Ca_influx["Calcium Influx"]
    membrane_perm["Membrane
Permeabilization"]
    apoptosis["Apoptotic
Cell Death"]
    microglia_act["Microglial
Activation"]
    phagocytosis["Phagocytic
Clearance"]
    neuroinflam["Neuroinflammation"]
    synapse_loss["Synaptic
Dysfunction"]
    neurodegeneration["Neurodegeneration"]
    huntingtons["Huntington's
Disease"]
    spinocer_ataxia["Spinocerebellar
Ataxia"]
    ATP_depletion["ATP Depletion"]
    oxidative_stress["Oxidative
Stress"]
    
    Ca_influx -->|"activates"| ANO6
    oxidative_stress -->|"activates"| ANO6
    ATP_depletion -->|"activates"| ANO6
    ANO6 -->|"promotes"| PS_exposure
    ANO6 -->|"increases"| membrane_perm
    PS_exposure -->|"signals"| microglia_act
    PS_exposure -->|"promotes"| phagocytosis
    membrane_perm -->|"triggers"| apoptosis
    microglia_act -->|"causes"| neuroinflam
    apoptosis -->|"leads to"| synapse_loss
    neuroinflam -->|"exacerbates"| neurodegeneration
    synapse_loss -->|"contributes to"| neurodegeneration
    neurodegeneration -->|"manifests in"| huntingtons
    neurodegeneration -->|"manifests in"| spinocer_ataxia

    classDef central fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#ffffff
    classDef protective fill:#1a3a2a,stroke:#81c784,stroke-width:2px,color:#ffffff
    classDef pathological fill:#3a1a1a,stroke:#ef5350,stroke-width:2px,color:#ffffff
    classDef regulatory fill:#2a1a3a,stroke:#ce93d8,stroke-width:2px,color:#ffffff
    classDef disease fill:#3a2a1a,stroke:#ffa726,stroke-width:2px,color:#ffffff
    
    class ANO6 central
    class phagocytosis protective
    class PS_exposure,membrane_perm,apoptosis,microglia_act,neuroinflam,synapse_loss,neurodegeneration,Ca_influx,ATP_depletion,oxidative_stress pathological
    class huntingtons,spinocer_ataxia disease

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (1)

Source	Relation	Type	Str
NFAT	regulates	protein	0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Does tau aggregation specifically cause PS externalization in vesicles independe

neurodegeneration | 2026-04-11 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The debate revealed a fundamental gap in understanding whether tau pathology dir

closed · Rounds: 4 · Score: 0.30 · 2026-04-21

Related Research

Hypotheses and analyses mentioning ANO6 in their description or question text

No additional research found