| Gene Symbol | NFAT5 |
| Full Name | Nuclear Factor of Activated T Cells 5 |
| Aliases | NFAT5PROTEIN |
| Protein Type | Transcription Factor |
| Function | NFAT5 (Nuclear Factor of Activated T Cells 5), also known as TonEBP (Tonicity-Responsive Enhancer Binding Protein), is a transcription factor that plays crucial roles in cellular stress responses. |
| Primary Expression | neurons, astrocytes, and microglia, where it contributes to: [@biomarkers2016] - Hippocampal synaptic plasticity - Astrocyte responses to injury - Mic |
| Pathways | Mapk |
| GeneCards | NFAT5 |
| Human Protein Atlas | NFAT5 |
| Rel-homology region (RHR) | DNA-binding domain at N-terminus (residues 1-487) |
| Transactivation domain | C-terminal region for cofactor recruitment |
| N-terminal regulatory domain | Contains the tonicity-sensing region |
| Dimerization interface | Forms homodimers for DNA binding |
| Multiple phosphorylation sites | Regulates subcellular localization [1] |
| DNA-binding domain | Binds to osmotic response elements (ORE) |
| Associated Diseases | Carcinoma |
| Interactions | AND, CANCER, CD4, CYTOKINES, GENES, JUN |
| KG Connections | 24 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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