| Gene Symbol | MAPK7 |
| Full Name | Mitogen-Activated Protein Kinase 7 |
| Chromosome | 17p11.2 |
| Protein Type | Kinase |
| Function | MAPK7/ERK5 is activated by upstream MAPKKs, specifically MEK5, which phosphorylates ERK5 at TEY motif within its activation loop [@mekerk]. |
| Primary Expression | the brain with high levels in [@mapk]: - Hippocampus (CA1-CA3 regions) - Cerebral cortex (layer |
| Pathways | MAPK, MAPK signaling |
| UniProt ID | [Q13115](https://www.uniprot.org/uniprot/Q13115) |
| Ensembl ID | ENSG00000166401 |
| OMIM | 602534 |
| GeneCards | MAPK7 |
| Human Protein Atlas | MAPK7 |
| Neurogenesis | Controls neural progenitor cell proliferation and differentiation |
| Synaptic plasticity | Essential for long-term potentiation (LTP) and memory formation |
| Neuronal survival | Mediates neurotrophic factor signaling (BDNF, NGF) |
| Associated Diseases | neurodegeneration |
| KG Connections | 14 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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