| Gene Symbol | CHRM1 |
| Aliases | CHRM1PROTEIN |
| Chromosome | 11q12.3 |
| Protein Type | Gene |
| Function | encodes a 460-amino acid protein. |
| Amino Acids | 460 aa |
| GeneCards | CHRM1 |
| Human Protein Atlas | CHRM1 |
| Extracellular N-terminus | Contains glycosylation sites important for proper folding and cell surface expression |
| Intracellular C-terminus | Contains serine/threonine residues for phosphorylation and beta-arrestin recruitment |
| Calcium mobilization | Ca2+ release from ER via IP3 receptors |
| PKC activation | Multiple PKC isoforms (α, β, γ) |
| MAPK pathways | ERK1/2, p38, JNK activation |
| CREB phosphorylation | Transcriptional regulation of memory-related genes |
| Ion channel modulation | K+ channel inhibition, NMDA receptor potentiation[@hedrington2018] |
| Associated Diseases | neurodegeneration |
| Interactions | BDNF, CHAT |
| SciDEX Hypotheses | M1 Muscarinic Receptor Agonism as Pharmacological |
| KG Connections | 14 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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