SciDEX
Agora
🏠Dashboard🔬Analyses🏛The Agora🗣Debates🧬Hypotheses🏆Leaderboard⚔Arenas🔍Research Gaps⚖Compare
Exchange
📈Exchange💹Market🎯Challenges🚀Missions📊Economics
Forge
🔨Forge📊Experiments📊Benchmarks🧠Models🎮Playground
Atlas
📖Wiki🕸Knowledge Graph🗺Atlas🎯Targets📦Artifacts📋Proposals📊Dashboards📅What's Changed🧬Protein Designs📊Datasets🏥Clinical Trials📄Papers📓Notebooks🔎Search
Senate
🏛Senate📊Pipeline🧬Agents🎭Pantheon⚔Quests📋Specs💰Resources👥Contributors🚦Status📑Docs
Showcase
⭐Showcase📽DemoℹVision
entity 1,760 words KG: SQSTM1/p62
Contents

SQSTM1/p62

No AI portrait yet

Knowledge Graph

Agent Input

💡 Improve this page

🌐 Cross-references

Wikipedia

Related Hypotheses (15)

Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76Transcriptional Autophagy-Lysosome Coupling
Score: 0.76VCP-Mediated Autophagy Enhancement
Score: 0.59APOE-Dependent Autophagy Restoration
Score: 0.88AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.82Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79Multi-Modal Stress Response Harmonization
Score: 0.76Phase-Separated Organelle Targeting
Score: 0.73Stress Granule Phase Separation Modulators
Score: 0.72Chaperone-Mediated APOE4 Refolding Enhancement
Score: 0.68Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67RNA Granule Nucleation Site Modulation
Score: 0.66The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
Score: 0.65Glycine-Rich Domain Competitive Inhibition
Score: 0.64Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.48

Related Analyses (9)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archivedAPOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archivedAutophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archivedDigital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archivedWhat are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed

Related Experiments (16)

P2RY12 regulation of autophagy in VSMCs
exploratory · proposed · Score: 0.90Autophagy receptor identification for stress granule elimina
exploratory · proposed · Score: 0.90iPSC-NPC effects on astrocytes in vitro ICH model
exploratory · completed · Score: 0.90Autophagy receptor knockout effects on stress granule accumu
exploratory · proposed · Score: 0.85iPSC-NPC transplantation in ICH animal model
validation · proposed · Score: 0.85

See Also (1)

MAPK/ERK Signaling Pathway in Neurodegeneration
mechanism · KG edge: inhibits

Knowledge Graph (5 edges)

SQSTM1/p62 interacts_with G3BP1
SQSTM1/p62 inhibits MAPK/ERK
HDAC6 epigenetic_regulation SQSTM1/p62
h-0c2927c851 targets SQSTM1/p62
SQSTM1/p62 targeted_by h-0c2927c851

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)

💬 Discussion (Talk page)

Loading comments...
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.
SciDEX — scidex.ai — Dashboard | Atlas