gene 1,696 words KG: LETM1
Contents

LETM1 — Leucine Zipper and EF-Hand Containing Transmembrane Protein 1

🧬 Gene Info
Gene SymbolLETM1
Full NameLeucine Zipper and EF-Hand Containing Transmembrane Protein 1
Chromosome4p16.3
Functionencodes an essential mitochondrial inner membrane protein that plays critical roles in mitochondrial function, calcium homeostasis, and cellular metabolism.
Primary Expressiontissues with high metabolic demands, particularly the brain, cerebellum, heart, and skeletal mus
Molecular Weight81 kDa
Amino Acids739 aa
Exons14
Pathwaysoxidative stress response
Ensembl IDENSG00000168936
GeneCardsLETM1
Human Protein AtlasLETM1
Associated DiseasesAD, ALI, AMI, cancer, diabetes
InteractionsOVERVIEW
KG Connections48 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (8)

Purinergic Signaling Polarization Control
Score: 0.71
Mechanosensitive Ion Channel Reprogramming
Score: 0.70
Lipid Droplet Dynamics as Phenotype Switches
Score: 0.67
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.67
Mitochondrial Calcium Buffering Enhancement via MCU Modulati
Score: 0.65

Related Analyses (7)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (15)

MCU Gene
gene · KG edge: interacts_with
Accelerating Medicines Partnership for Alzheimer's Dise
institution · KG edge: implicated_in
Alpha-Synuclein Seeding Assays (RT-QuIC and PMCA)
biomarker · Pages share 3 hypotheses
Cell-Free DNA Biomarkers in Neurodegeneration
biomarker · Pages share 3 hypotheses
Exosomal Biomarkers in Neurodegeneration
biomarker · Pages share 3 hypotheses

Knowledge Graph (12 edges)

LETM1 regulates MCU
LETM1 regulates OVERVIEW
OVERVIEW regulates LETM1
LETM1 implicated_in cancer
LETM1 implicated_in heart failure
LETM1 implicated_in muscular disorders
MCU regulates LETM1
LETM1 mediates MITOCHONDRIAL CALCIUM EFFLUX
LETM1 interacts_with MCU
LETM1 mediates Mitochondrial Calcium Exchange

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