| Gene Symbol | LAP3 |
| Full Name | Leucine Aminopeptidase 3 |
| Aliases | Page for LAP3 |
| Function | LAP3 (Leucine Aminopeptidase 3) is a cytosolic metalloexopeptidase that hydrolyzes N-terminal amino acids from peptides and proteins. |
| Primary Expression | various cancers including glioblastoma |
| Ensembl ID | ENSG00000002587 |
| GeneCards | LAP3 |
| Human Protein Atlas | LAP3 |
| Protein Turnover | LAP3 participates in the degradation of misfolded and damaged proteins, working alongside the proteasome and lysosomal systems. |
| Antigen Processing | The enzyme generates antigenic peptides for presentation via MHC class I molecules, crucial for immune surveillance of abnormal cells. |
| Peptide Hormone Metabolism | LAP3 processes bioactive peptides including enkephalins, bradykinin, and angiotensin, modulating neuropeptide signaling in the brain. |
| Aβ peptides | Amyloid-beta fragments (1-40, 1-42) |
| α-synuclein | Toxic fragments of synuclein protein |
| Enkephalins | Endogenous opioid peptides |
| Cytokines | Pro-inflammatory peptide mediators |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!