protein 1,687 words KG: LAPTM4APROTEIN
Contents

LAPTM4A Protein — Lysosomal-Associated Transmembrane Protein 4 Alpha

🔬 Protein Info
Gene SymbolLAPTM4A
Full NameLysosomal Associated Transmembrane Protein 4 Alpha
AliasesLAPTM4APROTEIN
Chromosome2p23.3
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressionvarious tissues including the brain, where it supports neuronal survival and function
Subcellular LocalizationPrimarily lysosomal membranes
Amino Acids224 aa
PathwaysmTOR, mtor
UniProt ID[Q9Y3Q5](https://www.uniprot.org/uniprot/Q9Y3Q5)
Ensembl IDENSG00000137714
GeneCardsLAPTM4A
Human Protein AtlasLAPTM4A
Tissue distributionHighest expression in brain, kidney, liver, lung, and gastrointestinal tract
Subcellular distributionPrimarily lysosomal membranes, with ER pool
Associated Diseasesneurodegeneration
DatabasesGeneCardsNCBI GeneHPASTRING

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Related Hypotheses (11)

APOE-Dependent Autophagy Restoration
Score: 0.88
Senescence-Associated Myelin Lipid Remodeling
Score: 0.73
Lysosomal Enzyme Trafficking Correction
Score: 0.71
Lysosomal Calcium Channel Modulation Therapy
Score: 0.70
Lysosomal Positioning Dynamics Modulation
Score: 0.69
Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67
FOXO3-Longevity Pathway Epigenetic Reprogramming
Score: 0.63
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
Lysosomal Membrane Repair Enhancement
Score: 0.54

Related Analyses (10)

Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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