protein

KCNJ6

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KCNJ6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

21Connections

0Hypotheses

0Analyses

16Outgoing

5Incoming

0Experiments

0Debates

Summary

Page for KCNJ6 Protein (Kir3.2 Potassium Channel)

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🔬 Protein Info

Gene Symbol	KCNJ6
Full Name	Potassium Inwardly Rectifying Channel Subfamily J Member 6
Aliases	Kir3.2 Potassium Channel
Chromosome	21q22.12
Protein Type	Channel
Function	KCNJ6 (also known as Kir2.3 or GIRK2) is an inward rectifier potassium channel subunit highly expressed in the brain, particularly in dopaminergic neurons of the substantia nigra
Primary Expression	the brain, particularly in dopaminergic neurons of the substantia nigra
Molecular Weight	48 kDa
UniProt ID	P48051
NCBI Gene ID	3767
Ensembl ID	ENSG00000157542
OMIM	600726
GeneCards	KCNJ6
Human Protein Atlas	KCNJ6
Associated Diseases	Cancer, Ms
KG Connections	21 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: KCNJ6 — AlphaFold P48051 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

KCNJ6 — Potassium Inwardly Rectifying Channel Subfamily J Member 6

gene · 615 words

→

KCNJ6 Protein (Kir3.2 Potassium Channel)

protein · 595 words

→

Pathway Diagram

graph TD
    KCNJ6["KCNJ6"]
    Ms{"Ms"}
    KCNJ6 -->|"associated with"| Ms
    Cancer{"Cancer"}
    KCNJ6 -->|"associated with"| Cancer
    KCNJ5["KCNJ5"]
    KCNJ6 -->|"regulates"| KCNJ5
    CANCER["CANCER"]
    KCNJ6 -->|"associated with"| CANCER
    KCNJ3["KCNJ3"]
    KCNJ6 -->|"regulates"| KCNJ3
    KCNK2["KCNK2"]
    KCNJ6 -->|"regulates"| KCNK2
    KCNS1["KCNS1"]
    KCNJ6 -->|"regulates"| KCNS1
    neurodegeneration["neurodegeneration"]
    KCNJ6 -->|"implicated in"| neurodegeneration
    style KCNJ6 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (16)

Target	Relation	Type	Str
Als	expressed_in	disease	0.65
Neurodegeneration	expressed_in	disease	0.65
ALS	expressed_in	disease	0.65
Ms	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
SPTLC1	expressed_in	gene	0.60
JAG2	expressed_in	gene	0.60
CANCER	associated_with	gene	0.60
KCNJ5	regulates	gene	0.60
KCNJ3	regulates	gene	0.60
KCNK2	regulates	gene	0.60
KCNS1	regulates	gene	0.60
STRAP	expressed_in	gene	0.60
AND	expressed_in	gene	0.60
RAS	expressed_in	gene	0.60
Hippocampus	expressed_in	brain_region	0.55

Incoming (5)

Source	Relation	Type	Str
STRAP	expressed_in	gene	0.60
JAG2	expressed_in	gene	0.60
SPTLC1	expressed_in	gene	0.60
NEURODEGENERATION	expressed_in	gene	0.60
GENES	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning KCNJ6 in their description or question text

No additional research found