gene

KCNJ5

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KCNJ5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

7Connections

0Hypotheses

0Analyses

6Outgoing

1Incoming

0Experiments

0Debates

Summary

Potassium inward rectifier gene KCNJ5 (Kir3.4/GIRK4)

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🧬 Gene Info

Gene Symbol	KCNJ5
Full Name	Potassium Inwardly Rectifying Channel Subfamily J Member 5
Aliases	Kir3.4/GIRK4
Chromosome	11q24.3
Function	encodes the G protein-activated inward rectifier potassium channel 4 (Kir3.4/GIRK4)
Primary Expression	brain (1999)](https://pubmed
UniProt ID	P48547
NCBI Gene ID	3764
Ensembl ID	ENSG00000120457
OMIM	600734
GeneCards	KCNJ5
Human Protein Atlas	KCNJ5
GNB1/GNG2	G protein subunits that directly activate GIRK channels
Excitotoxicity	Pathological mechanism involving excessive neuronal activation
G protein-coupled receptor signaling	Upstream pathway regulating KCNJ5 channel function
Associated Diseases	Cancer, Ms
KG Connections	7 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: KCNJ5 — AlphaFold P48547 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

KCNJ5 Gene

gene · 637 words

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Pathway Diagram

graph TD
    KCNJ5["KCNJ5"]
    Ms{"Ms"}
    KCNJ5 -->|"associated with"| Ms
    Cancer{"Cancer"}
    KCNJ5 -->|"associated with"| Cancer
    CANCER["CANCER"]
    KCNJ5 -->|"associated with"| CANCER
    KCNJ3["KCNJ3"]
    KCNJ5 -->|"regulates"| KCNJ3
    KCNK2["KCNK2"]
    KCNJ5 -->|"regulates"| KCNK2
    KCNS1["KCNS1"]
    KCNJ5 -->|"regulates"| KCNS1
    neurodegeneration["neurodegeneration"]
    KCNJ5 -->|"implicated in"| neurodegeneration
    KCNJ6["KCNJ6"]
    KCNJ6 -->|"regulates"| KCNJ5
    style KCNJ5 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (6)

Target	Relation	Type	Str
Ms	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
CANCER	associated_with	gene	0.60
KCNJ3	regulates	gene	0.60
KCNK2	regulates	gene	0.60
KCNS1	regulates	gene	0.60

Incoming (1)

Source	Relation	Type	Str
KCNJ6	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning KCNJ5 in their description or question text

No additional research found