gene

HTR1A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HTR1A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

45Connections

0Hypotheses

0Analyses

29Outgoing

16Incoming

0Experiments

0Debates

Summary

HTR1A is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, expressed in. Associated with ALS, Als, Ms. Connected to 15 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	HTR1A
Full Name	5-Hydroxytryptamine Receptor 1A
Chromosome	5q12.3
Function	Adenylyl cyclase inhibition: Decreased cAMP production
Primary Expression	Raphe nuclei, Hippocampus, Cortex, Amygdala
Amino Acids	421 aa
Exons	1
Pathways	NF-κB
UniProt ID	P08908
NCBI Gene ID	3350
Ensembl ID	ENSG00000178394
GeneCards	HTR1A
Human Protein Atlas	HTR1A
Associated Diseases	ALS
Known Drugs/Compounds	D-limonene
Interactions	AND, CIRCADIAN RHYTHM, CRH, GABA
KG Connections	45 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: HTR1A — AlphaFold P08908 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

HTR1A Gene

gene · 1030 words

→

Pathway Diagram

graph TD
    HTR1A["HTR1A"]
    Ms{"Ms"}
    HTR1A -->|"activates"| Ms
    Als{"Als"}
    HTR1A -->|"activates"| Als
    HTR1A -->|"regulates"| Als
    ALS{"ALS"}
    HTR1A -->|"activates"| ALS
    Circadian_Rhythm(["Circadian Rhythm"])
    HTR1A -->|"activates"| Circadian_Rhythm
    CRH["CRH"]
    HTR1A -->|"activates"| CRH
    CIRCADIAN_RHYTHM["CIRCADIAN RHYTHM"]
    HTR1A -->|"activates"| CIRCADIAN_RHYTHM
    AND["AND"]
    HTR1A -->|"activates"| AND
    Hypothalamus["Hypothalamus"]
    HTR1A -->|"expressed in"| Hypothalamus
    Thalamus["Thalamus"]
    HTR1A -->|"expressed in"| Thalamus
    neurodegeneration["neurodegeneration"]
    HTR1A -->|"implicated in"| neurodegeneration
    CRH -->|"activates"| HTR1A
    CRH -->|"regulates"| HTR1A
    CIRCADIAN_RHYTHM -->|"activates"| HTR1A
    style HTR1A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (29)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:HTR1A	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
mitophagy	regulates	process	0.85
Insomnia	therapeutic_target	disease	0.85
Sepsis-Associated Encephalopathy	modulates	disease	0.80
TAU	expresses	gene	0.70
Ms	activates	disease	0.65
Als	activates	disease	0.65
HYPOTHALAMUS	increases	brain_region	0.65
ALS	activates	disease	0.65
Als	regulates	disease	0.65
THALAMUS	increases	brain_region	0.65
CRH	activates	gene	0.60
GABA	activates	gene	0.60
TAU	causes	gene	0.60
CIRCADIAN RHYTHM	activates	gene	0.60
Circadian Rhythm	activates	pathway	0.60
thalamus	expressed_in	brain_region	0.60
ALS	associated_with	disease	0.60
AND	activates	gene	0.60
MTNR1A	targets	gene	0.60
MTNR1B	targets	gene	0.60
Hypothalamus	expressed_in	brain_region	0.55
Thalamus	expressed_in	brain_region	0.55
IL6	co_expressed_with	gene	0.50
MTNR1A	co_expressed_with	gene	0.50
HYPOTHALAMUS	activates	concept	0.50
HYPOTHALAMUS	co_discussed	brain_region	0.40
THALAMUS	co_discussed	brain_region	0.40

Incoming (16)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:HTR1A	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
D-limonene	targets	compound	0.75
CIRCADIAN RHYTHM	activates	gene	0.60
CDK5	expresses	gene	0.60
CDK5	causes	gene	0.60
CRH	activates	gene	0.60
GABRA1	targets	gene	0.60
GABA	activates	gene	0.60
CRH	regulates	gene	0.60
GABRB2	targets	gene	0.60
GABRA1	co_expressed_with	gene	0.50
GABRB2	co_expressed_with	protein	0.50
HYPOTHALAMUS	associated_with	brain_region	0.45
BDNF	co_discussed	gene	0.45
CREB	co_discussed	gene	0.45

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning HTR1A in their description or question text

No additional research found