gene

HDAC10

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HDAC10: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

15Connections

0Hypotheses

0Analyses

12Outgoing

3Incoming

0Experiments

0Debates

Summary

Histone Deacetylase 10 - role in autophagy regulation, neuroinflammation, and neurodegenerative disease

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🧬 Gene Info

Gene Symbol	HDAC10
Aliases	Histone Deacetylase 10
Chromosome	22q13.33.
Protein Type	Gene
Function	is a class IIb histone deacetylase encoded by the HDAC10 gene located on chromosome 22q13.
Primary Expression	both neurons and glia, with astrocytic and microglial expression particularly relevant to understanding its role in neuroinflammation
Subcellular Localization	and function
Molecular Weight	78 kDa
Amino Acids	669 aa
Exons	16
Pathways	Epigenetic
GeneCards	HDAC10
Human Protein Atlas	HDAC10
N-terminal catalytic domain (aa 1-370)	Contains the active site residues required for histone deacetylase activity
Nuclear export signal (NES)	Located at residues 85-95, mediating cytoplasmic localization
Associated Diseases	Alzheimer's disease, Parkinson's disease
Interactions	AND, DNMT3A, HDAC1
KG Connections	15 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

HDAC10 Gene

gene · 2089 words

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HDAC10 Protein

protein · 639 words

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Pathway Diagram

graph TD
    HDAC10["HDAC10"]
    Als{"Als"}
    HDAC10 -->|"therapeutic_target"| Als
    Carcinoma{"Carcinoma"}
    HDAC10 -->|"therapeutic_target"| Carcinoma
    Cancer{"Cancer"}
    HDAC10 -->|"therapeutic_target"| Cancer
    Tumor{"Tumor"}
    HDAC10 -->|"activates"| Tumor
    HDAC1(["HDAC1"])
    HDAC10 -->|"activates"| HDAC1
    DNMT3A(["DNMT3A"])
    HDAC10 -->|"activates"| DNMT3A
    AND(["AND"])
    AND -->|"activates"| HDAC10
    style HDAC10 fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#ce93d8

Outgoing (12)

Target	Relation	Type	Str
Als	therapeutic_target	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Tumor	activates	disease	0.65
CANCER	therapeutic_target	gene	0.60
Epigenetic	activates	pathway	0.60
HDAC1	activates	gene	0.60
DNMT3A	activates	gene	0.60
VEGF	therapeutic_target	gene	0.60
EGF	therapeutic_target	gene	0.60
EGFR	therapeutic_target	gene	0.60
epigenetic regulation	participates_in	pathway	0.60

Incoming (3)

Source	Relation	Type	Str
AND	activates	gene	0.60
DNMT3A	activates	gene	0.60
HDAC1	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning HDAC10 in their description or question text

No additional research found