protein

GRM3PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GRM3PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Mglur3 Protein — Glutamate Metabotropic Receptor 3 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

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🔬 Protein Info

Gene Symbol	GRM3PROTEIN
Full Name	Metabotropic Glutamate Receptor 3
Protein Type	Receptor
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	Brain (cortex, hippocampus, basal ganglia), glial cells
Molecular Weight	98 kDa (879 aa)
Amino Acids	879 aa
UniProt ID	Q14832
GeneCards	GRM3PROTEIN
Human Protein Atlas	GRM3PROTEIN
Venus Fly Trap (VFT) Domain	Large extracellular glutamate-binding domain (approximately 560 aa), forms homodimers
Cysteine-Rich Domain (CRD)	Approximately 80 aa, connects VFT to transmembrane region, essential for signal transduction
Associated Diseases	aging, Als, Alzheimer, Bipolar
Interactions	DAO, DISC1, G72, GRIN2B, GRM4, NCAM1
KG Connections	123 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: GRM3PROTEIN — AlphaFold Q14832 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

mGluR3 Protein — Glutamate Metabotropic Receptor 3

protein · 1066 words

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Pathway Diagram

graph TD
    GRM3PROTEIN["GRM3PROTEIN"]
    neurodegeneration["neurodegeneration"]
    GRM3PROTEIN -->|"implicated_in"| neurodegeneration
    style GRM3PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GRM3PROTEIN in their description or question text

No additional research found