| Gene Symbol | GRM3PROTEIN |
| Full Name | Metabotropic Glutamate Receptor 3 |
| Protein Type | Receptor |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | Brain (cortex, hippocampus, basal ganglia), glial cells |
| Molecular Weight | 98 kDa (879 aa) |
| Amino Acids | 879 aa |
| UniProt ID | Q14832 |
| GeneCards | GRM3PROTEIN |
| Human Protein Atlas | GRM3PROTEIN |
| Venus Fly Trap (VFT) Domain | Large extracellular glutamate-binding domain (approximately 560 aa), forms homodimers |
| Cysteine-Rich Domain (CRD) | Approximately 80 aa, connects VFT to transmembrane region, essential for signal transduction |
| Associated Diseases | aging, Als, Alzheimer, Bipolar |
| Interactions | DAO, DISC1, G72, GRIN2B, GRM4, NCAM1 |
| KG Connections | 123 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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