gene

GABPA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GABPA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

11Connections

0Hypotheses

0Analyses

5Outgoing

6Incoming

0Experiments

0Debates

Summary

Comprehensive information on GABPA, an ETS transcription factor critical for mitochondrial function and neuronal survival in Alzheimer's and Parkinson's diseases.

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🧬 Gene Info

Gene Symbol	GABPA
Full Name	GA Binding Protein Transcription Factor Alpha Subunit
Chromosome	21q21.3
Protein Type	Transcription Factor
Function	is a member of the ETS (E26 transformation-specific) family of transcription factors.
Molecular Weight	51 kDa
Amino Acids	454 aa
Exons	11
Pathways	Epigenetic
UniProt ID	Q06546
NCBI Gene ID	2551
Ensembl ID	ENSG00000154727
OMIM	137143
GeneCards	GABPA
Human Protein Atlas	GABPA
Associated Diseases	neurodegeneration
Interactions	CANCER, EGFR, ERK1, KDM5C, MYC, TERT
KG Connections	11 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: GABPA — AlphaFold Q06546 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

GABPA - GA Binding Protein Transcription Factor Alpha Subunit

gene · 1677 words

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Pathway Diagram

graph TD
    GABPA["GABPA"]
    Als{"Als"}
    GABPA -->|"activates"| Als
    Cancer{"Cancer"}
    GABPA -->|"activates"| Cancer
    Tumor{"Tumor"}
    GABPA -->|"inhibits"| Tumor
    Glioblastoma{"Glioblastoma"}
    GABPA -->|"activates"| Glioblastoma
    Epigenetic(["Epigenetic"])
    GABPA -->|"activates"| Epigenetic
    neurodegeneration["neurodegeneration"]
    GABPA -->|"implicated in"| neurodegeneration
    GABPB1["GABPB1"]
    GABPB1 -->|"binds"| GABPA
    KDM5C["KDM5C"]
    KDM5C -->|"activates"| GABPA
    MYC["MYC"]
    MYC -->|"activates"| GABPA
    EGFR["EGFR"]
    EGFR -->|"activates"| GABPA
    CANCER["CANCER"]
    CANCER -->|"activates"| GABPA
    ERK1["ERK1"]
    ERK1 -->|"activates"| GABPA
    TERT["TERT"]
    TERT -->|"activates"| GABPA
    style GABPA fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (5)

Target	Relation	Type	Str
Als	activates	disease	0.65
Cancer	activates	disease	0.65
Tumor	inhibits	disease	0.65
Glioblastoma	activates	disease	0.65
Epigenetic	activates	pathway	0.60

Incoming (6)

Source	Relation	Type	Str
KDM5C	activates	gene	0.60
MYC	activates	gene	0.60
EGFR	activates	gene	0.60
ERK1	activates	gene	0.60
TERT	activates	gene	0.60
CANCER	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GABPA in their description or question text

No additional research found