gene

G3BP2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about G3BP2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

38Connections

0Hypotheses

0Analyses

28Outgoing

10Incoming

0Experiments

0Debates

Summary

Page for G3BP2 - Ras-GTPase-Activating Protein-Binding Protein 2

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🧬 Gene Info

Gene Symbol	G3BP2
Full Name	Ras-GTPase-Activating Protein-Binding Protein 2
Aliases	Page for G3BP2, Page for G3BP2 Protein
Chromosome	4p16.3
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	56 kDa
Amino Acids	523 aa
Pathways	NF-κB, MAPK
UniProt ID	[Q9UWR1](https://www.uniprot.org/uniprot/Q9UWR1)
Ensembl ID	ENSG00000138798
GeneCards	G3BP2
Human Protein Atlas	G3BP2
RRM Domains (RNA Recognition Motifs)	Two RRM domains (RRM1 and RRM2) for RNA binding
RG-rich Region	Arginine-glycine rich region for protein-protein interactions
NTF2-like Domain	Mediates homodimerization and stress granule targeting
Associated Diseases	Als, Cancer
Interactions	CAPRIN1, G3BP1, Proteasome, RNA, TDP-43
KG Connections	38 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

G3BP2 - Ras-GTPase-Activating Protein-Binding Protein 2

gene · 961 words

→

G3BP2 Protein - Ras-GTPase-Activating Protein-Binding Protein 2

protein · 793 words

→

Pathway Diagram

graph TD
    G3BP2["G3BP2"]
    Cancer{"Cancer"}
    G3BP2 -->|"interacts with"| Cancer
    Als{"Als"}
    G3BP2 -->|"interacts with"| Als
    Tumor{"Tumor"}
    G3BP2 -->|"interacts with"| Tumor
    G3BP2 -->|"associated with"| Cancer
    G3BP2 -->|"associated with"| Als
    G3BP2 -->|"expressed in"| Cancer
    Atherosclerosis{"Atherosclerosis"}
    G3BP2 -->|"expressed in"| Atherosclerosis
    Cardiac{"Cardiac"}
    G3BP2 -->|"expressed in"| Cardiac
    G3BP2 -->|"expressed in"| Tumor
    G3BP1["G3BP1"]
    G3BP2 -->|"activates"| G3BP1
    Mtor(["Mtor"])
    G3BP2 -->|"interacts with"| Mtor
    G3BP2 -->|"inhibits"| G3BP1
    CAPRIN1["CAPRIN1"]
    CAPRIN1 -->|"interacts with"| G3BP2
    style G3BP2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (28)

Target	Relation	Type	Str
RNA	activates	gene	0.65
Als	activates	disease	0.65
Tumor	expressed_in	disease	0.65
Als	interacts_with	disease	0.65
Tumor	interacts_with	disease	0.65
Cancer	associated_with	disease	0.65
Als	associated_with	disease	0.65
Cancer	expressed_in	disease	0.65
Atherosclerosis	expressed_in	disease	0.65
Cardiac	expressed_in	disease	0.65
Cancer	interacts_with	disease	0.65
ALS	associated_with	disease	0.60
Mtor	interacts_with	pathway	0.60
T Cell	activates	cell_type	0.60
Proteasome	activates	protein	0.60
G3BP1	activates	gene	0.60
G3BP1	inhibits	gene	0.60
G3BP1	associated_with	gene	0.60
G3BP1	interacts_with	gene	0.60
RNA	regulates	gene	0.55
oxidative stress response	participates_in	pathway	0.55
neurons	expressed_in	cell_type	0.55
RNA	inhibits	gene	0.55
TDP-43	inhibits	gene	0.55
Brainstem	expressed_in	brain_region	0.55
neurodegeneration	regulates	disease	0.55
TDP-43	activates	gene	0.55
TDP-43	regulates	gene	0.55

Incoming (10)

Source	Relation	Type	Str
G3BP1	activates	gene	0.65
RNA	activates	gene	0.60
FMRP	associated_with	gene	0.60
CAPRIN1	interacts_with	gene	0.60
G3BP1	associated_with	gene	0.60
G3BP1	regulates	gene	0.55
G3BP1	inhibits	gene	0.55
G3BP1	targets	gene	0.55
FMRP	co_expressed_with	protein	0.50
G3BP1	co_expressed_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning G3BP2 in their description or question text

No additional research found