gene

FAM171A2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FAM171A2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

29Connections

0Hypotheses

0Analyses

25Outgoing

4Incoming

0Experiments

0Debates

Summary

FAM171A2 Gene — Neuronal Receptor for Alpha-Synuclein

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🧬 Gene Info

Gene Symbol	FAM171A2
Full Name	Neuronal Receptor for Alpha-Synuclein
Chromosome	10q21.3
Function	is a gene encoding a neuronal transmembrane protein that functions as a receptor for alpha-synuclein fibrils.
Subcellular Localization	positions FAM171A2 to intercept extracellular
Amino Acids	614 aa
Exons	12
Pathways	Oxidative Stress
UniProt ID	[Q6ZMP3](https://www.uniprot.org/uniprot/Q6ZMP3)
Ensembl ID	ENSG00000171970
GeneCards	FAM171A2
Human Protein Atlas	FAM171A2
Substantia nigra	Highest expression in dopaminergic neurons of the substantia nigra pars compacta — the exact neuronal population that degenerates in Parkinson's disease
Cerebral cortex	Moderate expression in cortical neurons, particularly layer 5 pyramidal neurons
Hippocampus	Expression in CA1 and CA3 pyramidal neurons and dentate gyrus granule cells
Associated Diseases	Parkinson
Interactions	CAT, GPX1, GRN, SOD1, TNF
KG Connections	29 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

FAM171A2 Gene — Neuronal Receptor for Alpha-Synuclein

gene · 2057 words

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Pathway Diagram

graph TD
    FAM171A2["FAM171A2"]
    Ms{"Ms"}
    FAM171A2 -->|"regulates"| Ms
    Parkinson{"Parkinson"}
    FAM171A2 -->|"regulates"| Parkinson
    neurodegeneration["neurodegeneration"]
    FAM171A2 -->|"implicated in"| neurodegeneration
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PARKINSON_S_DISEASE -->|"regulates"| FAM171A2
    AND["AND"]
    AND -->|"regulates"| FAM171A2
    PARKINSON["PARKINSON"]
    PARKINSON -->|"regulates"| FAM171A2
    style FAM171A2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (25)

Target	Relation	Type	Str
Parkinson	regulates	disease	0.65
Ms	regulates	disease	0.65
Inflammation	activates	disease	0.65
Oxidative Stress	activates	pathway	0.60
GPX1	activates	gene	0.60
CAT	activates	gene	0.60
SOD1	activates	gene	0.60
TNF	activates	gene	0.60
NF-kB signaling	participates_in	pathway	0.60
oxidative stress response	participates_in	pathway	0.60
Neuron	regulates	cell_type	0.60
Parkinson	associated_with	disease	0.60
PARKINSON	regulates	gene	0.60
AND	regulates	gene	0.60
PARKINSON'S DISEASE	regulates	gene	0.60
Α-Synuclein	regulates	protein	0.60
GRN	associated_with	gene	0.60
GRN	activates	gene	0.60
Neuron	expressed_in	cell_type	0.55
neurons	expressed_in	cell_type	0.55
SYNUCLEIN	regulates	concept	0.50
α-SYNUCLEIN	regulates	concept	0.50
Parkinson's Disease	regulates	disease	0.50
disease	regulates	disease	0.50
PARKINSON'S	regulates	concept	0.50

Incoming (4)

Source	Relation	Type	Str
PARKINSON'S DISEASE	regulates	gene	0.60
PARKINSON	regulates	gene	0.60
AND	regulates	gene	0.60
GRN	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning FAM171A2 in their description or question text

No additional research found