| Gene Symbol | DVL2 |
| Full Name | Dishevelled Segment Polarity Protein 2 |
| Chromosome | 17p13.1 |
| Protein Type | Scaffold Protein |
| Function | Wnt signaling: Central mediator of canonical and non-canonical Wnt pathways |
| Molecular Weight | 82 kDa |
| Amino Acids | 740 aa |
| Exons | 15 |
| Pathways | Wnt |
| GeneCards | DVL2 |
| Human Protein Atlas | DVL2 |
| Synapse Formation | DVL2 regulates the formation of excitatory synapses by promoting postsynaptic density protein 95 (PSD-95) clustering and recruiting AMPA-type glutamate receptors to synaptic sites [11]. |
| Synaptic Plasticity | Through its interactions with CaMKII and other synaptic proteins, DVL2 contributes to long-term potentiation (LTP) and long-term depression (LTD), cellular correlates of learning and memory [1]. |
| Axon Guidance | DVL2 mediates guidance cue responses that direct neuronal axons to their correct targets during development and regeneration [4]. |
| Highest Expression | Cerebral cortex, hippocampus, and cerebellum show the highest DVL2 expression levels throughout life [1]. |
| Associated Diseases | neurodegeneration |
| KG Connections | 11 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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