gene

DPM1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DPM1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

5Connections

0Hypotheses

0Analyses

4Outgoing

1Incoming

0Experiments

0Debates

Summary

Page for DPM1 Gene (Dolichol-Phosphate Mannosyltransferase Subunit 1)

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🧬 Gene Info

Gene Symbol	DPM1
Full Name	DPM1 (Dolichol-Phosphate Mannosyltransferase Subunit 1)
Aliases	Dolichol-Phosphate Mannosyltransferase Subunit 1
Chromosome	20q13.13
Protein Type	Gene
Function	The DPM1 gene encodes the catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex [@dpm].
UniProt ID	O60711
NCBI Gene ID	8813
Ensembl ID	ENSG00000024219
GeneCards	DPM1
Human Protein Atlas	DPM1
Mannose Transfer	Catalyzes the transfer of mannose from GDP-mannose to dolichol-phosphate
DPM Synthesis	Produces dolichol-phosphate mannose as the key intermediate
Glycosylation Initiation	DPM is the essential donor for N-linked protein glycosylation
Protein N-glycosylation	Over 50% of human proteins are glycosylated
Associated Diseases	Congenital Disorders of Glycosylation
Interactions	DPM2, DPM3
KG Connections	5 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: DPM1 — AlphaFold O60711 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

DPM1 Gene (Dolichol-Phosphate Mannosyltransferase Subunit 1)

gene · 540 words

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Pathway Diagram

flowchart TD
    DPM1(["DPM1"])
    Dolichylphosphate_Mannose("Dolichylphosphate Mannose")
    DPM2(["DPM2"])
    DPM3(["DPM3"])
    Congenital_Disorders_of_Glycosylation["Congenital Disorders of Glycosyl..."]
    neurodegeneration["neurodegeneration"]

    DPM1 -->|"participates in"| Dolichylphosphate_Mannose
    DPM1 -->|"interacts with"| DPM2
    DPM1 -->|"interacts with"| DPM3
    DPM1 -->|"associated with"| Congenital_Disorders_of_Glycosylation
    DPM3 -->|"stabilizes"| DPM1
    DPM1 -->|"implicated in"| neurodegeneration

    style DPM1 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff

Outgoing (4)

Target	Relation	Type	Str
Dolichylphosphate Mannose	participates_in	process	0.90
DPM2	interacts_with	gene	0.90
DPM3	interacts_with	gene	0.90
Congenital Disorders of Glycosylation	associated_with	disease	0.80

Incoming (1)

Source	Relation	Type	Str
DPM3	stabilizes	gene	0.80

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DPM1 in their description or question text

No additional research found