Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about DPM3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No AI portrait yet
| Gene Symbol | DPM3 |
| Full Name | DPM3 (Dolichol-Phosphate Mannosyltransferase Subunit 3) |
| Aliases | Dolichol-Phosphate Mannosyltransferase Subunit 3 |
| Chromosome | 1q22 |
| Protein Type | Gene |
| Function | The DPM3 gene encodes the third subunit of the dolichol-phosphate mannose (DPM) synthase complex, which is essential for protein N-glycosylation and glycolipid biosynthesis [@dolicholphosphate]. |
| UniProt ID | Q9BXS5 |
| NCBI Gene ID | 54344 |
| Ensembl ID | ENSG00000133030 |
| GeneCards | DPM3 |
| Human Protein Atlas | DPM3 |
| N-linked Protein Glycosylation | Transfer of mannose to nascent polypeptides in the endoplasmic reticulum |
| Glycolipid Biosynthesis | Synthesis of glycosylphosphatidylinositol (GPI) anchors |
| C-mannosylation | Rare type of protein glycosylation |
| Synaptic Proteins | Many synaptic receptors and adhesion molecules require proper glycosylation |
| Associated Diseases | neurodegeneration |
| Interactions | DPM1 |
| KG Connections | 3 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
DPM3["DPM3"]
DPM1["DPM1"]
DPM2["DPM2"]
neurodegeneration["neurodegeneration"]
DPM1 -->|"interacts with"| DPM3
DPM3 -->|"stabilizes"| DPM1
DPM2 -->|"stabilizes"| DPM3
DPM3 -->|"implicated in"| neurodegeneration
style DPM3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#fff
style DPM1 fill:#1a237e,stroke:#ce93d8,stroke-width:2px,color:#fff
style DPM2 fill:#1a237e,stroke:#ce93d8,stroke-width:2px,color:#fff
style neurodegeneration fill:#1a1a2e,stroke:#888,stroke-width:2px,color:#fff| Target | Relation | Type | Str |
|---|---|---|---|
| DPM1 | stabilizes | gene | 0.80 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning DPM3 in their description or question text
No additional research found