| Gene Symbol | CHD1L |
| Full Name | Chromodomain Helicase DNA-Binding Protein 1-Like |
| Chromosome | 1q21.1 |
| Protein Type | SNF2 family chromatin remodeler |
| Function | CHD1L belongs to the SNF2 family of ATP-dependent chromatin remodelers. |
| Primary Expression | neurons and glial cells, with particular enrichment in regions associated with learning and memory |
| Molecular Weight | 110 kDa |
| Pathways | epigenetic regulation |
| GeneCards | CHD1L |
| Human Protein Atlas | CHD1L |
| Chromatin Remodeling | Uses ATP hydrolysis to slide, eject, or restructure nucleosomes, making DNA accessible for transcription, replication, and repair |
| DNA Damage Response | Recruited to sites of DNA double-strand breaks where it promotes chromatin relaxation for repair factor access |
| Transcriptional Regulation | Modulates gene expression by altering chromatin accessibility at promoter and enhancer regions |
| Cell Cycle Regulation | Participates in S-phase progression and mitotic chromosome condensation [@zhang2020] |
| DNA Repair Deficits | CHD1L expression is reduced in AD brain tissue, potentially contributing to accumulated DNA damage in neurons |
| Associated Diseases | neurodegeneration |
| KG Connections | 3 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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