| Gene Symbol | CFL1 |
| Aliases | CFL1PROTEIN |
| Function | Cofilin 1 is a small actin-binding protein (19 kDa) that promotes the disassembly and reassembly of actin filaments. |
| Subcellular Localization | ** Cytoskeleton, actin filaments, nucleus [@hotulainen2006] |
| Molecular Weight | 19 kDa |
| Amino Acids | 166 aa |
| Pathways | Apoptosis |
| Ensembl ID | ENSG00000132716 |
| GeneCards | CFL1 |
| Human Protein Atlas | CFL1 |
| LIMK1/Cofilin pathway | PAK1/LIMK1 phosphorylation inhibits cofilin activity |
| PIP2 signaling | Membrane phosphoinositides regulate cofilin membrane association |
| pH sensitivity | Activity increases at acidic pH, relevant during neuronal activity |
| Associated Diseases | Als |
| Interactions | EFHD2 |
| KG Connections | 19 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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