concept

BLOOD-BRAIN BARRIER INTEGRITY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BLOOD-BRAIN BARRIER INTEGRITY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

72Connections

0Hypotheses

3Analyses

2Outgoing

50Incoming

0Experiments

3Debates

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💡 Concept Info

Name	BLOOD-BRAIN BARRIER INTEGRITY

Pathway Diagram

graph TD
    BLOOD_BRAIN_BARRIER_INTEGRITY["BLOOD-BRAIN BARRIER INTEGRITY"]
    CLDN5["CLDN5"] -->|"component_of"| BLOOD_BRAIN_BARRIER_INTEGRITY
    A1_Astrocytes["A1 Astrocytes"] -->|"downregulates"| BLOOD_BRAIN_BARRIER_INTEGRITY
    Dolutegravir["Dolutegravir"] -->|"inhibits"| BLOOD_BRAIN_BARRIER_INTEGRITY
    A1_Reactive_Astrocytes["A1 Reactive Astrocytes"] -->|"downregulates"| BLOOD_BRAIN_BARRIER_INTEGRITY
    Adherens_Junction_Components["Adherens Junction Components"] -->|"regulates"| BLOOD_BRAIN_BARRIER_INTEGRITY
    CX43["CX43"] -->|"involved_in"| BLOOD_BRAIN_BARRIER_INTEGRITY
    Butyrate["Butyrate"] -.protects against.-> BLOOD_BRAIN_BARRIER_INTEGRITY

Outgoing (2)

Target	Relation	Type	Str
cognitive decline	protects_against	phenotype	0.85
Cerebral Small Vessel Disease	involved_in	disease	0.73

Incoming (70)

Source	Relation	Type	Str
Deubiquitinating Enzymes	regulates	enzyme	0.95
CLDN5	regulates	protein	0.95
mitochondrial_transfer	associated_with	mechanism	0.95
CLDN5	component_of	protein	0.95
CLDN5	involved_in	protein	0.90
A1 Astrocytes	downregulates	phenotype	0.90
Dolutegravir	associated_with	drug	0.90
DTG	associated_with	drug	0.90
40102948	improves	paper	0.90
40102948	improved	paper	0.90
A1 Reactive Astrocytes	downregulates	phenotype	0.90
Adherens Junction Components	regulates	protein	0.90
TDP-43	associated_with	protein	0.90
Dolutegravir	inhibits	drug	0.90
Mfn2 deletion	causes	unknown	0.90
CXCR7	regulates	receptor	0.88
CX43	involved_in	gene	0.88
mitochondrial_dysfunction	contributes_to	mechanism	0.85
pericytes	associated_with	cell_type	0.85
MMP9	associated_with	protein	0.85
Ams-17	associated_with	compound	0.85
lipid metabolism dysregulation	associated_with	process	0.85
FGFR1-SIRT1	regulates	pathway	0.85
PI3K/AKT	regulates	pathway	0.85
ANXA1	associated_with	protein	0.85
ANXA2	associated_with	protein	0.85
Indoxyl Sulfate	associated_with	compound	0.85
Butyrate	protects_against	compound	0.85
Acetate	protects_against	compound	0.85
Propionate	protects_against	compound	0.85
mitochondrial dysfunction	associated_with	process	0.85
Paracellular Permeability	associated_with	phenotype	0.85
SASP factors	associated_with	protein	0.85
endothelial dysfunction	associated_with	phenotype	0.85
Autophagy	protects_against	process	0.85
deubiquitinating enzymes	regulates	protein	0.85
PI3K/AKT Pathway	regulates	pathway	0.85
LRP1	biomarker_for	gene	0.85
Dysbiosis	associated_with	phenotype	0.85
CTNNB1	associated_with	protein	0.80
Border-Associated Macrophages	regulates	cell_type	0.80
Short-Chain Fatty Acids	protects_against	compound	0.80
ASTROCYTE	involved_in	cell_type	0.80
time-restricted feeding	associated_with	process	0.80
CLDN5	mediates	gene	0.80
NRF2	involved_in	protein	0.80
ANXA2	regulates	protein	0.80
NF-ΚB	involved_in	protein	0.80
TNF-α	compromises	protein	0.80
ANXA1	regulates	protein	0.80