protein

BAG2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BAG2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

16Connections

0Hypotheses

0Analyses

9Outgoing

7Incoming

0Experiments

0Debates

Summary

BAG2 is a protein involved in neurodegeneration research. Key relationships include: interacts with, associated with, regulates. Associated with Aging, Ms. Connected to 17 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	BAG2
Protein Type	Chaperone
Function	BAG2 (BCL2 Associated Athanogene 2) is a co-chaperone protein that modulates the Hsp70/Hsp90 chaperone systems.
Subcellular Localization	</strong></td><td>Cytoplasm, Nucleus (minor)</td></tr>
Molecular Weight	22.5 kDa
Amino Acids	211 aa
Pathways	Proteasome
Ensembl ID	ENSG00000165168
GeneCards	BAG2
Human Protein Atlas	BAG2
ATPase Inhibition	Binds to Hsp70 ATPase domain, blocking substrate binding and release
Chaperone Complex Assembly	Forms ternary complexes with Hsp70 and client proteins
Protein Quality Control	Modulates the balance between refolding and degradation pathways
Protein Turnover	Influences the fate of misfolded proteins
Direct Tau Binding	BAG2 directly interacts with tau protein through its N-terminal region
Associated Diseases	Ms
Interactions	AUTOPHAGY, P62, SQSTM1, TAU, UBIQUITIN
KG Connections	16 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

BAG2 Protein

protein · 804 words

→

BAG2

gene · 757 words

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Pathway Diagram

graph TD
    BAG2["BAG2"]
    Ms{"Ms"}
    BAG2 -->|"associated with"| Ms
    Aging{"Aging"}
    BAG2 -->|"regulates"| Aging
    BAG2 -->|"regulates"| Ms
    SQSTM1["SQSTM1"]
    BAG2 -->|"interacts with"| SQSTM1
    P62["P62"]
    BAG2 -->|"interacts with"| P62
    Proteasome(["Proteasome"])
    BAG2 -->|"activates"| Proteasome
    Autophagy(["Autophagy"])
    BAG2 -->|"inhibits"| Autophagy
    BCL2["BCL2"]
    BAG2 -->|"associated with"| BCL2
    AND["AND"]
    BAG2 -->|"activates"| AND
    AUTOPHAGY["AUTOPHAGY"]
    BAG2 -->|"inhibits"| AUTOPHAGY
    neurodegeneration["neurodegeneration"]
    BAG2 -->|"implicated in"| neurodegeneration
    BCL2 -->|"associated with"| BAG2
    SQSTM1 -->|"interacts with"| BAG2
    P62 -->|"interacts with"| BAG2
    AGING["AGING"]
    AGING -->|"regulates"| BAG2
    HSP70["HSP70"]
    HSP70 -->|"associated with"| BAG2
    TAU["TAU"]
    TAU -->|"activates"| BAG2
    UBIQUITIN["UBIQUITIN"]
    UBIQUITIN -->|"activates"| BAG2
    style BAG2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (9)

Target	Relation	Type	Str
Ms	associated_with	disease	0.65
Aging	regulates	disease	0.65
Ms	regulates	disease	0.65
SQSTM1	interacts_with	gene	0.60
P62	interacts_with	gene	0.60
Proteasome	activates	pathway	0.60
Autophagy	inhibits	pathway	0.60
BCL2	associated_with	gene	0.60
AUTOPHAGY	inhibits	gene	0.60

Incoming (7)

Source	Relation	Type	Str
HSP70	associated_with	gene	0.60
BCL2	associated_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
P62	interacts_with	gene	0.60
TAU	activates	gene	0.60
UBIQUITIN	activates	gene	0.60
AGING	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning BAG2 in their description or question text

No additional research found