concept

AUTOPHAGY-LYSOSOME PATHWAY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AUTOPHAGY-LYSOSOME PATHWAY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

41Connections

5Hypotheses

2Analyses

24Outgoing

17Incoming

19Experiments

3Debates

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💡 Concept Info

Name	AUTOPHAGY-LYSOSOME PATHWAY
Key Genes/Proteins	AMPK, C9orf72, NLRP3, SQSTM1, TARDBP, TBK1
Related Diseases	AMYOTROPHIC LATERAL SCLEROSIS, AUTOPHAGY, DEMENTIA, FRONTOTEMPORAL DEMENTIA, MITOPHAGY

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Autophagy-Lysosome Pathway in Neurodegeneration

mechanism · 2348 words

→

Pathway Diagram

graph TD
    AUTOPHAGY_LYSOSOME_PATHWAY["AUTOPHAGY-LYSOSOME PATHWAY"]
    AUTOPHAGY_LYSOSOME_PATHWAY -->|"degrades"| NLRP3["NLRP3"]
    AUTOPHAGY_LYSOSOME_PATHWAY -->|"degrades"| SCIN["SCIN"]
    AUTOPHAGY_LYSOSOME_PATHWAY -->|"involved_in"| Glucocorticoid_Induced_Muscle_["Glucocorticoid-Induced Muscle Atrophy"]
    AUTOPHAGY_LYSOSOME_PATHWAY -->|"regulates"| alpha_synuclein["alpha-synuclein"]
    Schaftoside["Schaftoside"] -->|"activates"| AUTOPHAGY_LYSOSOME_PATHWAY
    extracellular_matrix_remodelin["extracellular matrix remodeling"] -->|"enhances"| AUTOPHAGY_LYSOSOME_PATHWAY
    CAMK2D["CAMK2D"] -->|"regulates"| AUTOPHAGY_LYSOSOME_PATHWAY
    ASTROCYTE["ASTROCYTE"] -->|"regulates"| AUTOPHAGY_LYSOSOME_PATHWAY
    Obestatin["Obestatin"] -->|"regulates"| AUTOPHAGY_LYSOSOME_PATHWAY
    MTOR["MTOR"] -->|"regulates"| AUTOPHAGY_LYSOSOME_PATHWAY
    mTOR["mTOR"] -->|"regulates"| AUTOPHAGY_LYSOSOME_PATHWAY
    alpha_synuclein -->|"inhibits"| AUTOPHAGY_LYSOSOME_PATHWAY

Outgoing (24)

Target	Relation	Type	Str
NLRP3	degrades	protein	0.90
TDP-43 Aggregation	involved_in	mechanism	0.85
SCIN	degrades	protein	0.85
Glucocorticoid-Induced Muscle Atrophy	involved_in	disease	0.80
NLRP3	regulates	protein	0.70
alpha-synuclein	regulates	protein	0.70
Parkinson's disease	associated_with	disease	0.70
FRONTOTEMPORAL DEMENTIA	associated_with	disease	0.45
RAPAMYCIN	associated_with	drug	0.45
DEMENTIA	associated_with	disease	0.45
TDP-43	associated_with	protein	0.45
SQSTM1	associated_with	gene	0.45
TARDBP	associated_with	gene	0.45
NEURON	associated_with	cell_type	0.45
AMPK	associated_with	gene	0.45
TFEB	associated_with	gene	0.45
ULK1	associated_with	gene	0.45
TBK1	associated_with	gene	0.45
C9orf72	associated_with	gene	0.45
NLRP3	associated_with	gene	0.45
UBIQUITIN	associated_with	protein	0.45
MITOPHAGY	associated_with	phenotype	0.45
MICROGLIA	associated_with	cell_type	0.45
AUTOPHAGY	associated_with	phenotype	0.45

Incoming (17)

Source	Relation	Type	Str
lnc-HIBADH-4/miR-326/CTSD	regulates	pathway	0.90
extracellular matrix remodeling	enhances	process	0.90
Schaftoside	activates	compound	0.90
TDP-43	inhibits	protein	0.90
CAMK2D	regulates	protein	0.85
OBST	regulates	protein	0.85
C9ORF72	dysregulates	gene	0.80
Obestatin	regulates	compound	0.80
Rapamycin	activates	drug	0.80
ASTROCYTE	regulates	cell_type	0.80
alpha-synuclein	inhibits	protein	0.70
MTOR	regulates	protein	0.70
mTOR	regulates	protein	0.70
FOXO1	participates_in	gene	0.62
VCP	participates_in	gene	0.49
STX17	participates_in	gene	0.47
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	disease	0.45

Targeting Hypotheses (5)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Transcriptional Autophagy-Lysosome Coupling	0.882	neurodegeneration	Autophagy-lysosome pathway convergence a
Early Proteasome Restoration Therapy	0.712	neurodegeneration	Gene expression changes in aging mouse b
Autophagosome Maturation Checkpoint Control	0.709	neurodegeneration	Autophagy-lysosome pathway convergence a
VCP-Mediated Autophagy Enhancement	0.571	Alzheimer's Disease	Tau propagation mechanisms and therapeut
HBOT (2.0 ATA, 60 min) activates TFEB-mediated autophagy-lys	0.560	neurodegeneration	What are the optimal oxygen pressure, du

Mentioning Analyses (2)

Scientific analyses that reference this entity

Tau propagation mechanisms and therapeutic interception points

neurodegeneration | 2026-04-04 | 15 hypotheses Top: 0.814

Autophagy-lysosome pathway convergence across neurodegenerative diseases

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.882

Experiments (19)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Meta-analysis of LRP1 C766T polymorphism and Alzheimer's disease susce	exploratory	Alzheimer's disease	0.950	0.00	human patients	proposed	N/A
Endothelial CD2AP knockdown effects on memory in male mice	validation	Alzheimer's disease	0.900	0.00	male mice	proposed	N/A
Amyloid plaque load analysis in triple-mutant mouse brains	exploratory	Alzheimer's disease	0.880	0.00	APP/PSEN1/GD3S-/- triple-trans	proposed	N/A
Reelin treatment rescue via ApoER2 in CD2AP mutant mice	validation	Alzheimer's disease	0.870	0.00	mice	proposed	N/A
Network Pharmacology Analysis of Shared AD Targets	exploratory	Alzheimer's disease	0.850	0.00	Computational network analysis	proposed	N/A
MRI Phenotyping Method Concordance in Serbian AD Cohort	clinical	Alzheimer's disease	0.850	0.00	human patients	proposed	N/A
Endothelin-1 receptor A antagonist rescue in male CD2AP mice	validation	Alzheimer's disease	0.850	0.00	male mice	proposed	N/A
Endothelin-1 receptor A antagonist rescue experiment	validation	Alzheimer's disease	0.850	0.00	mice	proposed	N/A
Neuroimmune modulation and Aβ clearance mechanisms	exploratory	Alzheimer's disease	0.820	0.00	Microglia and astrocytes	proposed	N/A
Competing endogenous RNA (ceRNA) network construction	exploratory	Alzheimer's disease	0.750	0.00	computational network analysis	proposed	N/A
Autophagy Enhancement Drug Screening for Neurodegeneration	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$6,550,000
Chaperone-Mediated Autophagy Dysfunction in PD - Experiment Design	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$5,460,000
Macroautophagy Dysfunction in PD - Experiment Design	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$5,460,000
Validate Mitochondria-Lysosome Contact Site Dysfunction in PD	validation	Parkinson's Disease	0.400	0.50	human	proposed	$2,730,000
Mutant Huntingtin (mHTT) Clearance Mechanisms — Therapeutic Target Val	validation	Neurodegeneration	0.400	0.50	human	proposed	$3,000,000
MLCS Quantification in Parkinson's Disease	validation	Parkinson's Disease	0.400	0.50	human	proposed	$2,730,000
Presymptomatic GRN Carrier Intervention Timing — Biomarker-Guided Ther	clinical	Neurodegeneration	0.400	0.50	human	proposed	$5,460,000
TMEM106B Haplotype as Genetic Modifier in FTD — Mechanism and Therapeu	validation	Neurodegeneration	0.400	0.50	human	proposed	$2,730,000
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment Design	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$7,500,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Autophagy and ALS: mechanistic insights and therapeutic implications. [PMID:34057020]	Chua JP, De Calbiac H, Kabashi E, Barmad	Autophagy	2022	2
Systemic Neurodegeneration and Brain Aging: Multi-Omics Disintegration, Proteost [PMID:40868276]	Voicu V, Toader C, Șerban M, Covache-Bus	Biomedicines	2025	1
Hepatocyte FoxO1 Deficiency Protects From Liver Fibrosis via Reducing Inflammati [PMID:37678798]	Pan Q, Gao M, Kim D, Ai W, Yang W, Jiang	Cell Mol Gastroenterol Hepatol	2024	1
Acetylation in the regulation of autophagy. [PMID:35435793]	Xu Y, Wan W	Autophagy	2023	1
Metabolic orchestration of cell death by AMPK-mediated phosphorylation of RIPK1. [PMID:37384704]	Zhang T, Xu D, Trefts E, Lv M, Inuzuka H	Science	2023	1
Cinobufagin induces FOXO1-regulated apoptosis, proliferation, migration, and inv [PMID:35176466]	Zhang L, Liang B, Xu H, Gong Y, Hu W, Ji	J Ethnopharmacol	2022	1
New insights regarding SNARE proteins in autophagosome-lysosome fusion. [PMID:32924745]	Tian X, Teng J, Chen J	Autophagy	2021	1
Metformin Improves Mitochondrial Respiratory Activity through Activation of AMPK [PMID:31693892]	Wang Y, An H, Liu T, Qin C, Sesaki H, Gu	Cell Rep	2019	1
AMPK-Mediated BECN1 Phosphorylation Promotes Ferroptosis by Directly Blocking Sy [PMID:30057310]	Song X, Zhu S, Chen P, Hou W, Wen Q, Liu	Curr Biol	2018	1
Obestatin controls the ubiquitin-proteasome and autophagy-lysosome systems in gl [PMID:28675664]	Cid-Díaz T, Santos-Zas I, González-Sánch	J Cachexia Sarcopenia Muscle	2017	1
Autophagosomes form at ER-mitochondria contact sites. [PMID:23455425]	Hamasaki M, Furuta N, Matsuda A, Nezu A,	Nature	2013	1
Gut Microbiota-Derived Tyrosol Alleviates Radiation-Induced Intestinal Injury vi [PMID:41800257]	Jin X, Xue H, Shi X, Zhou Y, Zhang J, Ze	International journal of biolo	2026	0
PTEN loss drives B7H3 upregulation via the mTORC2/FOXO/c-Myc axis to promote tum [PMID:41920736]	Wang Z, Jin N, Li X, Ma X, Feng Y, Yin K	Cell reports	2026	0
SNX16 functions as a nutrient-sensitive regulator of autophagosomal components r [PMID:41593027]	Que H, Rong Y	Autophagy	2026	0
TMEM259/MEMBRALIN is a non-canonical ER-phagy receptor that associates with MAN1 [PMID:41799849]	Camilleri JM, Zhang J, Wang T, Ahmad I,	Autophagy reports	2026	0
Mammalian lipophagy: process and function. [PMID:41681129]	Zhao R, Dai E, Kang R, Liu J, Klionsky D	Autophagy	2026	0
TAZ alleviates ischemic stroke injury by activating Foxo1: Usp1-mediated deubiqu [PMID:41921828]	["Xin Y", "Sun Y", "Pan E", "Li M", "Che	Free radical biology & medicin	2026	0
Unveiling the Genomic Landscape of Yan Goose (Anser cygnoides): Insights into Po [PMID:41594384]	Qi S, Ai Z, Cai Y, Zhang Y, Zhao W et al	Animals (Basel)	2026	0
Combining network pharmacology and multi-omics reveals the role of Shengdihuang- [PMID:41655545]	Cao X, Shang Y, Qu M, Kang Q, Xu Y et al	Phytomedicine	2026	0
Comparative transcriptomics of adherent and suspension chicken fibroblast cell l [PMID:41763754]	Contreras EJ, Nagarajan A, Bromberg BH,	Food Res Int	2026	0

Debates (3)

Multi-agent debates referencing this entity

Investigate prion-like spreading of tau pathology through connected brain region

closed · Rounds: 4 · Score: 0.90 · 2026-04-12

Multiple NDDs converge on autophagy-lysosome dysfunction. Are there universal th

closed · Rounds: 4 · Score: 0.90 · 2026-04-06

Tau propagation mechanisms and therapeutic interception points

closed · Rounds: 3 · Score: 0.95 · 2026-04-04