Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ATAXIN-2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | ATAXIN |
| Protein Family | Ataxin-2 family, RNA-binding proteins |
| Function | is a cytoplasmic RNA-binding protein encoded by the ATXN2 gene that plays critical roles in RNA metabolism, stress granule dynamics, and translational control |
| Subcellular Localization | Cytoplasm, stress granules, RNA processing bodies (P-bodies) |
| Molecular Weight | 140 kDa |
| Amino Acids | 1313 aa |
| Pathways | Tdp-43 |
| UniProt ID | Q99700 |
| GeneCards | ATAXIN |
| Human Protein Atlas | ATAXIN |
| Interactions | TDP-43 |
| KG Connections | 21 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
flowchart TD
N0["ATAXIN-2"]
N1["Tdp-43"]
N0 -->|"inhibits"| N1
N0 -->|"activates"| N1
N2["disease"]
N0 -->|"inhibits"| N2
N0 -->|"associated with"| N1
N3["CENTRAL NERVOUS SYSTEM"]
N0 -->|"associated with"| N3
N0 -->|"causes"| N1
N4["amyotrophic lateral sclerosis"]
N0 -->|"regulates"| N4
N5["PARKINSON"]
N0 -->|"regulates"| N5
N6["Parkinson's Disease"]
N0 -->|"regulates"| N6
N7["Ataxia"]
N0 -->|"regulates"| N7
N8["Neuron"]
N0 -->|"regulates"| N8
N0 -->|"regulates"| N2
N9["Spinocerebellar Ataxia"]
N0 -->|"regulates"| N9
N10["FTLD"]
N0 -->|"regulates"| N10
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
class N1 pathway
class N2 disease
class N4 gene
class N5 gene
class N6 disease
class N7 disease
class N9 disease| Target | Relation | Type | Str |
|---|---|---|---|
| TDP-43 mice | therapeutic_reduction_of_extends_lifespan_and_reduces_pathology | animal_model | 0.90 |
| TDP-43 | interacts_with | protein | 0.85 |
| amyotrophic lateral sclerosis | regulates | gene | 0.50 |
| PARKINSON | regulates | gene | 0.50 |
| Parkinson's Disease | regulates | disease | 0.50 |
| Ataxia | regulates | disease | 0.50 |
| Neuron | regulates | cell_type | 0.50 |
| disease | regulates | disease | 0.50 |
| Spinocerebellar Ataxia | regulates | disease | 0.50 |
| FTLD | regulates | concept | 0.50 |
| PARKINSON'S | regulates | concept | 0.50 |
| MOTOR NEURON | regulates | concept | 0.50 |
| Tdp-43 | inhibits | pathway | 0.50 |
| Tdp-43 | activates | pathway | 0.50 |
| disease | inhibits | disease | 0.50 |
| Tdp-43 | associated_with | pathway | 0.50 |
| CENTRAL NERVOUS SYSTEM | associated_with | concept | 0.50 |
| Tdp-43 | causes | pathway | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Ataxin-2 Polyglutamine Expansions Hijack G3BP1 to Form Toxic | 0.700 | neurodegeneration | How do disease-associated mutations in G |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning ATAXIN-2 in their description or question text
No additional research found