Contents

FUS Gene-Mechanism-Therapy Causal Chain — ALS/FTD

🔬 Protein Info

Gene Symbol	ent-gene-83d99ff1
Function	- Disrupted karyopherin trafficking
Inheritance	Autosomal dominant with high penetrance
Age of Onset	Typically 30-50 years (younger than SOD1-ALS)
Progression	Rapid — median survival 2-3 years from onset
Phenotypic Variability	Some mutations cause ALS-FTD overlap
KG Connections	14 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

No AI portrait yet

Knowledge Graph