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mechanism 2,248 words KG: ent-gene-45ba9650
Contents

PTPσ (PTPRS) in C9ORF72-ALS/FTD - PI3P Regulation Mechanism

🔬 Protein Info
Gene Symbolent-gene-45ba9650
Primary ExpressionPrimarily in nervous system — neurons and glia
Repeat expansionGGGGCC repeat in the first intron
Domain structureExtracellular carbonic anhydrase-like domains, transmembrane region, cytoplasmic tyrosine phosphatase domain
Synaptic plasticitymodulates NMDA receptor signaling
Axon regenerationregulates growth cone dynamics
Myelinationinfluences oligodendrocyte differentiation
Glial scar formationmodulates astrocyte reactivity
KG Connections6 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (19)

Cryptic Exon Silencing Restoration
Score: 0.53Cross-Seeding Prevention Strategy
Score: 0.69Glycine-Rich Domain Competitive Inhibition
Score: 0.64VCP-Mediated Autophagy Enhancement
Score: 0.59APOE-Dependent Autophagy Restoration
Score: 0.86AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.81Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.77Epigenetic Memory Erasure via TET2 Activation
Score: 0.74TET2-Mediated Demethylation Rejuvenation Therapy
Score: 0.71Reelin-Mediated Cytoskeletal Stabilization Protocol
Score: 0.69Partial Neuronal Reprogramming via Modified Yamanaka Cocktai
Score: 0.67Temporal TET2-Mediated Hydroxymethylation Cycling
Score: 0.66Arginine Methylation Enhancement Therapy
Score: 0.65KDM6A-Mediated H3K27me3 Rejuvenation
Score: 0.65DNMT1-Targeting Antisense Oligonucleotide Reset
Score: 0.65Epigenetic Memory Reprogramming for Alzheimer's Disease
Score: 0.61The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
Score: 0.65TFEB-PGC1α Mitochondrial-Lysosomal Decoupling
Score: 0.62RNA-Binding Competition Therapy for TDP-43 Cross-Seeding
Score: 0.47

Related Analyses (30)

RNA binding protein dysregulation across ALS FTD AD
neurodegeneration · archivedTDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · completedTDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archivedRNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completedRNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (25)

Progranulin Replacement Therapy for FTD — Vector Development
clinical · proposed · Score: 0.40Mechanism: C9orf72 Hexanucleotide Repeat Expansion in ALS/FT
validation · proposed · Score: 0.40C9orf72 Phenotype Divergence: ALS vs FTD Mechanism Study
clinical · proposed · Score: 0.40Autophagy Enhancement Drug Screening for Neurodegeneration
clinical · proposed · Score: 0.40Frontal and Temporal Lobe Selective Vulnerability in FTD — M
validation · proposed · Score: 0.40

Knowledge Graph (6 edges)

h-1111ac0598 targets ent-gene-45ba9650
ent-gene-45ba9650 targeted_by h-1111ac0598
h-f1c69043ea targets ent-gene-45ba9650
ent-gene-45ba9650 targeted_by h-f1c69043ea
h-b3e97952 targets ent-gene-45ba9650
ent-gene-45ba9650 targeted_by h-b3e97952

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