concept

ZEB1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ZEB1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

34Connections

0Hypotheses

0Analyses

17Outgoing

17Incoming

0Experiments

0Debates

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💡 Concept Info

Name	ZEB1
Key Genes/Proteins	ALOX5, ATM, ATXN3, GBM, GJA1
Related Diseases	epilepsy, glioblastoma
Related Pathways	ferroptosis, Interferon response, mitochondrial function, oxidative stress response

Pathway Diagram

graph TD
    ZEB1[ZEB1]
    ZEB1 -->|involved_in| Mitochondrial_Dysfunction[Mitochondrial Dysfunction]
    ZEB1 -->|regulates| Interferon_response[Interferon response]
    ZEB1 -->|participates in| ferroptosis[ferroptosis]
    ZEB1 -->|regulates| glioblastoma[glioblastoma]
    ZEB1 -->|participates in| mitochondrial_function[mitochondrial function]
    ZEB1 -->|expressed in| microglia[microglia]
    ZEB1 -->|participates in| ubiquitin_proteasome[ubiquitin-proteasome]
    PI3K_AKT[PI3K-AKT] -->|activates| ZEB1
    GBM[GBM] -->|regulates| ZEB1
    ATXN3[ATXN3] -->|activates| ZEB1
    benchmark_ot_ad_answer_key_ZEB[benchmark_ot_ad_answer_key:ZEB1] -->|data_in| ZEB1

Outgoing (17)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:ZEB1	data_in	dataset_row	0.00
HK2	upregulates	protein	0.95
HIF-1α signaling	activates	unknown	0.85
Mitochondrial Dysfunction	involved_in	process	0.85
Interferon response	regulates	pathway	0.70
epilepsy	associated_with	disease	0.60
ferroptosis	participates_in	pathway	0.60
glioblastoma	biomarker_for	disease	0.60
glioblastoma	activates	disease	0.60
glioblastoma	associated_with	disease	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
glioblastoma	inhibits	disease	0.60
oxidative stress response	participates_in	pathway	0.60
endothelial cells	expressed_in	cell_type	0.60
glioblastoma	regulates	disease	0.60
mitochondrial function	participates_in	pathway	0.60
microglia	expressed_in	cell_type	0.60

Incoming (17)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:ZEB1	data_in	dataset_row	0.00
PI3K-AKT	activates	pathway	0.85
ALOX5	associated_with	gene	0.60
ATM	associated_with	gene	0.60
GJA1	associated_with	gene	0.60
PARP14	associated_with	gene	0.60
TGFBR1	associated_with	gene	0.60
ATXN3	activates	gene	0.60
GBM	activates	gene	0.60
GBM	regulates	gene	0.60
ATXN3	inhibits	gene	0.60
GBM	inhibits	gene	0.60
ATXN3	biomarker_for	gene	0.60
GBM	biomarker_for	gene	0.60
ATXN3	associated_with	gene	0.60
GBM	associated_with	gene	0.60
ATXN3	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ZEB1 in their description or question text

No additional research found