concept

TRPML2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TRPML2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

26Connections

0Hypotheses

0Analyses

18Outgoing

8Incoming

0Experiments

0Debates

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💡 Concept Info

Name	TRPML2
Key Genes/Proteins	App, AUTOPHAGY, GENES, JUN, LYSOSOME, MCOLN1
Related Diseases	Als, ALS, Neurodegeneration
Related Pathways	Autophagy, autophagy pathway, Calcium Signaling

Pathway Diagram

graph TD
    TRPML2["TRPML2"]
    TRPML2 -->|"co_expressed_with"| TRPML1["TRPML1"]
    TRPML2 -->|"regulates"| Neurodegeneration["Neurodegeneration"]
    TRPML2 -->|"expressed in"| ALS["ALS"]
    TRPML2 -->|"expressed in"| Als["Als"]
    TRPML2 -->|"expressed in"| GENES["GENES"]
    TRPML2 -->|"expressed in"| AUTOPHAGY["AUTOPHAGY"]
    TRPML2 -->|"regulates"| JUN["JUN"]
    TRPML2 -->|"expressed in"| AND["AND"]
    MCOLN1["MCOLN1"] -->|"regulates"| TRPML2
    LYSOSOME["LYSOSOME"] -->|"regulates"| TRPML2
    NEURODEGENERATION["NEURODEGENERATION"] -->|"regulates"| TRPML2
    TRPML3["TRPML3"] -->|"expressed in"| TRPML2
    TRPML1 -->|"expressed in"| TRPML2
    AUTOPHAGY -->|"expressed in"| TRPML2
    JUN -->|"regulates"| TRPML2

Outgoing (18)

Target	Relation	Type	Str
TRPML1	interacts_with	protein	0.80
Neurodegeneration	regulates	disease	0.65
ALS	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
TRPML3	associated_with	gene	0.60
TRPML1	expressed_in	gene	0.60
MCOLN1	regulates	gene	0.60
TRPML3	expressed_in	gene	0.60
Fibroblast	regulates	cell_type	0.60
Raf	expressed_in	protein	0.60
App	regulates	protein	0.60
JUN	regulates	gene	0.60
Autophagy	expressed_in	pathway	0.60
Calcium Signaling	regulates	pathway	0.60
autophagy pathway	participates_in	pathway	0.60
AUTOPHAGY	expressed_in	gene	0.60
GENES	expressed_in	gene	0.60
Fibroblast	expressed_in	cell_type	0.55

Incoming (8)

Source	Relation	Type	Str
TRPML1	associated_with	gene	0.60
MCOLN1	regulates	gene	0.60
LYSOSOME	regulates	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
TRPML3	expressed_in	gene	0.60
TRPML1	expressed_in	gene	0.60
AUTOPHAGY	expressed_in	gene	0.60
JUN	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TRPML2 in their description or question text

No additional research found