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therapeutic 996 words KG: ent-gene-694200ea
Contents

GBA-Targeting Therapies

🔬 Protein Info
Gene SymbolGBA
Full NameTargeting Therapies
Functionis a critical gene in the intersection of lysosomal storage disorders and neurodegenerative diseases.
Molecular Weight60 kDa
Amino Acids536 aa
PathwaysAmyloid, Autophagy, Autophagy-Lysosomal Pathway, Chaperone, Epigenetic
Ensembl IDENSG00000177628
GeneCardsGBA
Human Protein AtlasGBA
Associated DiseasesAD, Aging, ALI, Als, Alzheimer
Known Drugs/CompoundsAAV.GMU01_SS3-GBA1, glucosylceramide, NCGC00188758
InteractionsABCD3, ACHE, Actin, AD, AGING, ALPHA-SYNUCLEIN
SciDEX HypothesesGlucosylceramide accumulation nucleates alpha-synu
KG Connections1589 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

Wikipedia

Related Hypotheses (11)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.38Smartphone-Detected Motor Variability Correction
Score: 0.74Microbial Metabolite-Mediated α-Synuclein Disaggregation
Score: 0.51Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.48Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79Phase-Separated Organelle Targeting
Score: 0.73Metabolic Switch Targeting for A1→A2 Repolarization
Score: 0.73DNMT1-Targeting Antisense Oligonucleotide Reset
Score: 0.65Proteostasis Enhancement via APOE Chaperone Targeting
Score: 0.72Targeting Bacterial Curli Fibrils to Prevent α-Synuclein Cro
Score: 0.64Trinucleotide Repeat Sequestration via CRISPR-Guided RNA Tar
Score: 0.61

Related Analyses (14)

GBA-Synuclein Loop Therapeutics for PD
neurodegeneration · completedAstrocyte Reactivity Subtypes in Neurodegeneration
neurodegeneration · archivedEpigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archivedMicroglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archivedAPOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived

Related Experiments (13)

Alpha-Synuclein Aggregation Triggers — Sporadic PD Initiatio
clinical · proposed · Score: 0.40Autophagy Enhancement Drug Screening for Neurodegeneration
clinical · proposed · Score: 0.40Genetic Risk Modifiers in DLB Phenotype
clinical · proposed · Score: 0.40DLB Treatment Response Biomarkers — Predicting Cholinesteras
clinical · proposed · Score: 0.40DNA Damage Repair Deficiency Validation Study in Parkinson's
clinical · completed · Score: 0.40

Knowledge Graph (4 edges)

ent-gene-694200ea data_in benchmark_ot_ad_answer_key:GBA
benchmark_ot_ad_answer_key:GBA data_in ent-gene-694200ea
ent-gene-694200ea participates_in_pathway R-HSA-9840310
ent-gene-694200ea participates_in_pathway R-HSA-390471

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