| Gene Symbol | SSBP1 |
| Chromosome | 14q12 |
| Function | encodes a mitochondrial single-stranded DNA-binding protein essential for mitochondrial DNA (mtDNA) maintenance, replication, and repair. |
| Molecular Weight | 17 kDa |
| Amino Acids | 172 aa |
| Pathways | Apoptosis, Mitochondrial Function |
| GeneCards | SSBP1 |
| Human Protein Atlas | SSBP1 |
| N-terminal Domain (1-50 aa) | Contains mitochondrial targeting sequence (MTS) for import into mitochondria. The N-terminus also participates in tetramer formation. |
| DNA-Binding Domain (50-150 aa) | The central region contains the OB-fold (oligosaccharide/oligonucleotide-binding fold), which provides the ssDNA binding activity. This domain is highly conserved across species. |
| Associated Diseases | Als, Alzheimer, Cancer, Glioblastoma, Ms |
| Interactions | ALZHEIMER, AND, APOE, APOPTOSIS, APP, CALB1 |
| KG Connections | 102 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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