concept

SCAP

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SCAP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

33Connections

5Hypotheses

0Analyses

20Outgoing

13Incoming

0Experiments

0Debates

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💡 Concept Info

Name	SCAP
Key Genes/Proteins	FAM134B, INSIG1, NLRP3, NR1H3
Related Diseases	Fatty Liver Disease
Related Pathways	autophagy pathway, lipid metabolism, pyroptosis, Smaild Pathway
Linked Hypotheses	2 hypotheses

Wiki Pages (1)

Knowledge base pages for this entity

SCAPER Gene

gene · 739 words

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Pathway Diagram

graph TD
    SCAP[SCAP]
    SCAP -->|regulates| SREBF[SREBF]
    SCAP -->|interacts| SREBP2[SREBP2]
    SCAP -->|involved_in| Lysosomal_Degradation[Lysosomal Degradation]
    SCAP -->|target for| Fatty_Liver_Disease[Fatty Liver Disease]
    SCAP -->|activates| STING[STING]
    SCAP -->|interacts| SREBF2[SREBF2]
    SCAP -->|activates| SREBF1[SREBF1]
    SCAP -->|interacts| SQSTM1[SQSTM1]
    lycorine[lycorine] -->|interacts| SCAP
    SQSTM1 -->|interacts| SCAP
    Lycorine[Lycorine] -->|binds| SCAP
    Smaild_Pathway[Smaild Pathway] -->|mediates| SCAP
    NLRP3[NLRP3] -->|activates| SCAP
    NR1H3[NR1H3] -->|activates| SCAP
    FAM134B[FAM134B] -->|regulates| SCAP

Outgoing (20)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:SCAP	data_in	dataset_row	0.00
SREBF	regulates	protein	0.95
SREBP2	interacts_with	protein	0.90
Lysosomal Degradation	involved_in	process	0.85
Fatty Liver Disease	therapeutic_target	disease	0.80
STING	activates	gene	0.70
SREBF2	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
STING	associated_with	gene	0.60
SREBP2	associated_with	gene	0.60
lipid metabolism	participates_in	pathway	0.60
oligodendrocytes	expressed_in	cell_type	0.60
SREBF1	activates	gene	0.60
SQSTM1	associated_with	gene	0.60
STING	interacts_with	gene	0.60
SREBP2	activates	gene	0.60
pyroptosis	participates_in	pathway	0.60
SREBP2	regulates	gene	0.60
autophagy pathway	participates_in	pathway	0.60
macrophages	expressed_in	cell_type	0.55

Incoming (13)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:SCAP	data_in	dataset_row	0.00
Lycorine	binds	compound	0.90
Lycorine	degrades	compound	0.90
lycorine	interacts_with	drug	0.90
lycorine	inhibits	drug	0.90
SQSTM1	interacts_with	protein	0.90
Smaild Pathway	mediates	pathway	0.80
FAM134B	regulates	gene	0.60
FAM134B	activates	gene	0.60
NLRP3	activates	gene	0.60
NLRP3	interacts_with	gene	0.60
NR1H3	activates	gene	0.60
INSIG1	activates	gene	0.60

Targeting Hypotheses (5)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
APOE4-driven lysosome-to-ER cholesterol transport failure re	0.690	molecular biology	Does APOE4's reduced lipid-binding direc
LPS-primed microglial trained immunity establishes persisten	0.670	neurodegeneration	Synaptic pruning by microglia in neurode
Endosomal escape determines whether transferred tau becomes	0.669	neurodegeneration	Seed-competent tau conformers in trans-s
APOE isoform modifies the C1q binding landscape, biasing C1q	0.590	neurodegeneration	Does C1q function differ based on subcel
APOE4 alters the accessible-cholesterol threshold sensed by	0.420	molecular biology	Does APOE4's reduced lipid-binding direc

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SCAP in their description or question text

No additional research found