Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RG1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | RG1 |
| Linked Hypotheses | 1 hypotheses |
Knowledge base pages for this entity
graph TD
RG1["RG1"]
RG1 -->|"treats"| Alzheimer_S_Disease["Alzheimer'S Disease"]
RG1 -->|"activates"| AMPK["AMPK"]
RG1 -->|"inhibits"| DRP1["DRP1"]
RG1 -->|"treats"| Cognitive_Dysfunction["Cognitive Dysfunction"]
RG1 -->|"activates"| AMPK_Drp1_Signaling_Pathway["AMPK/Drp1 Signaling Pathway"]
RG1 -->|"downregulates"| A__Deposition["Abeta Deposition"]
RG1 -.protects against.-> Mitochondrial_Dysfunction["Mitochondrial Dysfunction"]
RG1 -->|"upregulates"| Mitochondrial_Membrane_Potenti["Mitochondrial Membrane Potential"]| Target | Relation | Type | Str |
|---|---|---|---|
| Alzheimer'S Disease | treats | disease | 0.95 |
| Cognitive Dysfunction | treats | phenotype | 0.95 |
| Amyloid Beta Deposition | associated_with | phenotype | 0.95 |
| DRP1 | inhibits | protein | 0.95 |
| AMPK | activates | protein | 0.95 |
| Mitochondrial Membrane Potential | upregulates | biomarker | 0.90 |
| Mitochondrial Dysfunction | protects_against | phenotype | 0.90 |
| Reactive Oxygen Species | associated_with | process | 0.90 |
| AMPK/Drp1 Signaling Pathway | activates | pathway | 0.90 |
| Aβ Deposition | downregulates | biomarker | 0.90 |
| Neuronal Loss | associated_with | process | 0.85 |
| Cognitive Dysfunction | protects_against | phenotype | 0.85 |
| Amyloid Beta Deposition | inhibits | process | 0.85 |
| Alzheimer's Disease | treats | disease | 0.85 |
| Oxidative Stress | associated_with | process | 0.80 |
| Neuroinflammation | associated_with | process | 0.80 |
| Apoptosis | inhibits | process | 0.80 |
| Tau Phosphorylation | inhibits | process | 0.80 |
| Synaptic Function | regulates | process | 0.80 |
| Tau Protein Phosphorylation | inhibits | process | 0.80 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| BACE1/NRG1 Axis Dysfunction Drives Excitatory/Inhibitory Imb | 0.743 | neurodegeneration | What are the physiological functions of |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Neuregulin1-ErbB4 Signaling Involved in Acupuncture Promoting Myelin Regeneratio [PMID:41801841] | Shen J, Zhao Y, Jiang C, Huang Y, Wang L | J Vis Exp | 2026 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning RG1 in their description or question text
No additional research found