protein

PU.1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PU.1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

23Connections

2Hypotheses

2Analyses

13Outgoing

10Incoming

0Experiments

3Debates

Summary

PU.1 transcription factor - microglial master regulator

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🔬 Protein Info

Gene Symbol	PU.1
Aliases	PU.1 transcription factor
Molecular Weight	31 kDa
Pathways	Cholesterol
Interactions	IL-10, INPP5D expression, MAPK, MERTK
KG Connections	21 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

SPI1 Gene - PU.1

gene · 2569 words

→

PU.1 Protein (SPI1)

protein · 878 words

→

Pathway Diagram

graph TD
    PU_1["PU.1"]
    PU_1 -->|"regulates"| Macrophage_Polarization["Macrophage Polarization"]
    PU_1 -->|"activates"| apoptosis["apoptosis"]
    PU_1 -->|"activates"| Cholesterol["Cholesterol"]
    PU_1 -->|"activates"| Lymphoma["Lymphoma"]
    PU_1 -->|"activates"| Macrophage["Macrophage"]
    PU_1 -->|"activates"| B_Cell["B Cell"]
    PU_1 -->|"activates"| MACROPHAGES["MACROPHAGES"]
    PU_1 -->|"activates"| MAPK["MAPK"]
    S1PR1["S1PR1"] -->|"upregulates"| PU_1
    S1P1["S1P1"] -->|"upregulates"| PU_1
    MERTK["MERTK"] -->|"activates"| PU_1
    IL_10["IL-10"] -->|"activates"| PU_1
    late["late"] -->|"activates"| PU_1
    mTOR["mTOR"] -->|"activates"| PU_1

Outgoing (13)

Target	Relation	Type	Str
transcriptional_regulation	mediates	process	0.90
Macrophage Polarization	regulates	process	0.85
Lipid Metabolism	regulates	process	0.80
lipid droplet accumulation	promotes	phenotype	0.80
NF-κB	induces_transcriptional_reprogramming_via	gene	0.80
INPP5D expression	activates	gene	0.70
apoptosis	activates	process	0.50
Cholesterol	activates	pathway	0.50
Lymphoma	activates	disease	0.50
Macrophage	activates	cell_type	0.50
B Cell	activates	cell_type	0.50
MACROPHAGES	activates	concept	0.50
MAPK	activates	gene	0.50

Incoming (10)

Source	Relation	Type	Str
41193812	governs	paper	0.90
41193812	becomes downregulated following	paper	0.90
SPI1	encodes	gene	0.90
S1P1	upregulates	receptor	0.85
APOE4	induces_transcriptional_reprogramming_via	gene	0.80
APOE	regulates	gene	0.60
MERTK	activates	gene	0.50
IL-10	activates	protein	0.50
late	activates	disease	0.50
mTOR	activates	entity	0.50

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
HDAC2-Specific Repression of PU.1 Pioneer Factor Target Site	0.415	neurodegeneration	How does HDAC1/2 deletion specifically e
PU.1 Degradation via PROTAC for Inflammatory Microglial Pola	0.408	neurodegeneration	Microglial subtypes in neurodegeneration