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protein 660 words KG: TDP43PROTEIN
Contents

TDP-43 Protein

🔬 Protein Info
Gene SymbolTDP
Full Name43 Protein
AliasesTDP43PROTEIN
Chromosome1p36.
FunctionTDP-43 is central to the pathogenesis of amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and is commonly co-detected in Alzheimer's disease as a secondary pathology.
Subcellular Localizationsignal (
GeneCardsTDP
Human Protein AtlasTDP
Associated DiseasesAls, Alzheimer, Alzheimer's disease, Amyotrophic Lateral Sclerosis, Dementia
InteractionsActin, AKT, ALS, amyotrophic lateral sclerosis, AMYOTROPHIC LATERAL SCLEROSIS, ATXN2
KG Connections244 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (16)

Cross-Seeding Prevention Strategy
Score: 0.69Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.77PARP1 Inhibition Therapy
Score: 0.74Stress Granule Phase Separation Modulators
Score: 0.72R-Loop Resolution Enhancement Therapy
Score: 0.68RNA Granule Nucleation Site Modulation
Score: 0.66Arginine Methylation Enhancement Therapy
Score: 0.65Ephrin-B2/EphB4 Axis Manipulation
Score: 0.64Glycine-Rich Domain Competitive Inhibition
Score: 0.64Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62TREM2-mediated microglial tau clearance enhancement
Score: 0.62Low Complexity Domain Cross-Linking Inhibition
Score: 0.62Cryptic Exon Silencing Restoration
Score: 0.53Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62RNA-Binding Competition Therapy for TDP-43 Cross-Seeding
Score: 0.47

Related Analyses (12)

What determines the selectivity and efficiency of intercellu
neurodegeneration · completedTDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · completedTDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archivedWhat is the therapeutic window between insufficient and toxi
neurodegeneration · completedMitochondrial transfer between astrocytes and neurons
neurodegeneration · archived

Related Experiments (24)

cGAS/STING pathway activation by TDP-43-released mtDNA
exploratory · proposed · Score: 0.95TDP-43 mitochondrial invasion and mtDNA release in iPSC moto
exploratory · proposed · Score: 0.90TDP-43 mutant mouse model cGAS/STING pathway analysis
validation · proposed · Score: 0.90TDP-43 mitochondrial invasion and DNA release via mPTP
exploratory · proposed · Score: 0.90cGAS/STING pathway validation in TDP-43 mutant mice
validation · proposed · Score: 0.85

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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