protein 1,185 words KG: SQSTM1PROTEIN
Contents

SQSTM1/p62 Protein

🔬 Protein Info
Gene SymbolSQSTM1
Full NameSQSTM1 (p62/Sequestosome-1)
AliasesSQSTM1PROTEIN
Chromosome5q35.3.
Protein TypeProtein
Functionp62/SQSTM1 functions as: [@jones2021]
Molecular Weight~62 kDa (hence p62)
PathwaysAdaptive Immunity, Akt, Autophagy, Autophagy-lysosomal pathway, Cell Cycle
UniProt IDQ13501
GeneCardsSQSTM1
Human Protein AtlasSQSTM1
Associated DiseasesAD, ADH, Aging, ALI, Als
Known Drugs/CompoundsATC161, COENZYME Q10, DEXAMETHASONE, N-degrons, Palmostatin B, rapamycin
Interactions4E-BP1, ABCA1, ABCD3, ABCG1, ACAT1, ACHE
SciDEX HypothesesRutin enhances chaperone and autophagic clearance
KG Connections4058 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

No AI portrait yet

Knowledge Graph

Related Hypotheses (6)

Transcriptional Autophagy-Lysosome Coupling
Score: 0.88
APOE-Dependent Autophagy Restoration
Score: 0.85
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.67
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62

Related Analyses (6)

Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (8)

Autophagy receptor identification for stress granule elimina
exploratory · proposed · Score: 0.90
iPSC-NPC effects on astrocytes in vitro ICH model
exploratory · proposed · Score: 0.90
Autophagy receptor knockout effects on stress granule accumu
exploratory · proposed · Score: 0.85
P2RY12 regulation of autophagy in VSMCs
exploratory · proposed · Score: 0.90
iPSC-NPC transplantation in ICH animal model
validation · proposed · Score: 0.85

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)