| Gene Symbol | RAB7 |
| Aliases | RAB7, member RAS oncogene family |
| Function | RAB7 is a master regulator of late endosomal/lysosomal trafficking: - Late endosome maturation: Regulates transition from early to late endosomes - Lysosomal fusion: Controls SNARE-mediated fusion wit |
| Subcellular Localization | </b></td><td>Late endosomes, lysosomes, autophagosomes</td></tr> |
| Molecular Weight | 23 kDa |
| Amino Acids | 207 aa |
| Exons | 7 |
| Pathways | PI3K |
| GeneCards | RAB7 |
| Human Protein Atlas | RAB7 |
| Prenylation | C-terminal cysteine residues are prenylated (geranylgeranylation), enabling membrane association. |
| Phosphorylation | RAB7 can be phosphorylated, modulating its activity and effector interactions. |
| Ubiquitination | RAB7 can be ubiquitinated, influencing its turnover and function. |
| Associated Diseases | Als, Ataxia, disease, Neurodegeneration |
| Interactions | ALZHEIMER'S DISEASE, AMYLOID, AND, ATP6V1G1, AUTOPHAGY, CCT5 |
| KG Connections | 218 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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