| Gene Symbol | OPTINEURIN |
| Aliases | OPTINEURINPROTEIN |
| Chromosome | 10p13 |
| Protein Family | Selective autophagy receptors (SQSTM1-like) |
| Protein Type | Adaptor Protein |
| Function | The UBAN domain recognizes ubiquitin chains on mitochondria, while the LIR motif recruits autophagosomes. |
| Molecular Weight | ~67 kDa |
| Amino Acids | 577 |
| Pathways | Amyloid, Autophagy, Myelination, Necroptosis, Oxidative Stress |
| UniProt ID | Q96CV9 |
| GeneCards | OPTINEURIN |
| Human Protein Atlas | OPTINEURIN |
| N-terminal domain | Mediates protein-protein interactions [@sahlender2005] |
| Leucine zipper (LZ) | Dimerization and protein interactions [@swiateckaurban2010] |
| Ubiquitin-binding domain (UBD) | Binds monoubiquitin and polyubiquitin chains [@bose2012] |
| Associated Diseases | Als, Alzheimer, Amyotrophic Lateral Sclerosis, Dementia, Frontotemporal Dementia |
| Interactions | ABCD3, ACTB, Actin, Akt, AKT1, AKT1S1 |
| KG Connections | 1215 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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