| Gene Symbol | IDE |
| Aliases | Page for IDE Gene |
| Chromosome | 10q23.33 |
| Protein Type | Protease |
| Function | Peptide hydrolysis, amyloid clearance |
| Subcellular Localization | IDE is found in multiple cellular compartments: |
| Molecular Weight | 110 kDa |
| Amino Acids | 1019 aa |
| Pathways | Oxidative Stress |
| NCBI Gene ID | 3416 |
| GeneCards | IDE |
| Human Protein Atlas | IDE |
| N-terminal catalytic domain | Contains the zinc-binding motif (HXXEH) |
| C-terminal domain | Regulates substrate binding and dimerization |
| Substrate-binding cavity | Large internal chamber (~10,000 ų) |
| Associated Diseases | Als, Alzheimer, Alzheimer's disease, Diabetes, Insulin Resistance |
| Known Drugs/Compounds | metformin |
| Interactions | ACE, ACE2, AD, ADAM10, AKT, ALZHEIMER |
| KG Connections | 254 knowledge graph edges |
| Databases | GeneCardsUniProtHPASTRING |
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